In vitro activity of fluoroquinolones (gatifloxacin, levofloxacin and trovafloxacin) and seven other antibiotics against Streptococcus pneumoniae
Título del documento: In vitro activity of fluoroquinolones (gatifloxacin, levofloxacin and trovafloxacin) and seven other antibiotics against Streptococcus pneumoniae
Revista: The brazilian journal of infectious diseases
Base de datos: PERIÓDICA
Número de sistema: 000290664
ISSN: 1413-8670
Autores: 1
Instituciones: 1Universidade de Sao Paulo, Escola de Medicina, Sao Paulo. Brasil
Año:
Periodo: Abr
Volumen: 5
Número: 2
Paginación: 50-52
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Experimental
Resumen en inglés In recent years, the level of resistance of S. pneumoniae to beta-lactam and/or macrolides has increased around the world including some countries in South America. Because of this resistance, it is necessary to test the therapeutic alternatives for treating this pathogen, including the newer quinolones. This study was carried out in order to compare the in vitro activity of fluoroquinolones gatifloxacin, levofloxacin and trovafloxacin, to penicillin G, amoxicillin, amoxicillin-clavulanate, cufuroxime sodium, ceftriaxone, azithromycin and clarithromycin, against 300 strains of S. pneumoniae. Of the 300 samples tested, 18.6% were not susceptible to penicillin (56 strains) and 7% (21 strains) were resistant to the second generation cephalosporin. Among the macrolides, resistance ranged from 6.7% for clarithromycin to 29.6% for azithromycin. Susceptibility to the newer quinolones was 100% including the 56 strains not susceptible to penicillin. Among the 10 antibiotics evaluated, the fluoroquinolones gatifloxacin, levofloxacin, and trovafloxacin displayed high levels of in vitro activity against S. pneumoniae
Disciplinas: Medicina
Palabras clave: Farmacología,
Microbiología,
Neumología,
Streptococcus pneumoniae,
Resistencia antimicrobiana,
Pruebas de susceptibilidad,
Infecciones,
Vías respiratorias
Keyword: Medicine,
Microbiology,
Pharmacology,
Pneumology,
Streptococcus pneumoniae,
Antimicrobial resistance,
Susceptibility tests,
Infections,
Respiratory tract
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