| Revista: | The brazilian journal of infectious diseases |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000290656 |
| ISSN: | 1413-8670 |
| Autores: | Caramelli, Bruno1 Bernoche, Claudia Y.S.M. de Sartori, Ana M. C Sposito, Andrei C Santos, Raul D Monachini, Maristela C Strabelli, Tania Uip, Davi |
| Instituciones: | 1Universidade de Sao Paulo, Instituto do Coracao, Sao Paulo. Brasil |
| Año: | 2001 |
| Periodo: | Dic |
| Volumen: | 5 |
| Número: | 6 |
| Paginación: | 332-338 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental |
| Resumen en inglés | ABSTRACT Hyperlipidemia has been frequently recorded as a side effect of treating HIV patients with protease inhibitors (PI). This study was initiated to analyze the modifications on blood lipids in HIV-patients receiving PI and the safety and efficacy of the treatment with fenofibrate. Total (TC) and HDL-cholesterol, triglycerides (TG), and CD4+ T-cell counts were measured in 30 HAART-naive patients (Group I) before and after PI introduction. In a second phase of the study, the effects of fenofibrate on lipids, CPK, CD4+, and viral load were determined in 13 patients (Group II) with elevated TC or TG. In Group I, 60% of the patients showed TC or TG elevations. Average increments of 31% and 146% in TC and TG respectively (p<0.0006 and p<0.0001) were observed. In Group II, fenofibrate treatment was associated with decrements of 6.6% (TC) and 45.7% (TG) (p=0.07 and 0.0002) and no modifications on CPK, CD4+, and viral load. In conclusion, hyperlipidemia is common during the treatment of HIV with protease inhibitors, and fenofibrate appears to be an effective and safe choice for its treatment |
| Disciplinas: | Química, Medicina |
| Palabras clave: | Bioquímica, Terapéutica y rehabilitación, Inmunología, Colesterol, Lípidos, VIH, Triglicéridos |
| Keyword: | Chemistry, Medicine, Biochemistry, Therapeutics and rehabilitation, Cholesterol, Lipids, HIV, Triglycerides, Immunology |
| Texto completo: | Texto completo (Ver HTML) |
