Fluconazole susceptibility of Brazilian Candida isolates assessed by a disk diffusion method



Título del documento: Fluconazole susceptibility of Brazilian Candida isolates assessed by a disk diffusion method
Revista: The brazilian journal of infectious diseases
Base de datos: PERIÓDICA
Número de sistema: 000290694
ISSN: 1413-8670
Autores: 1


Instituciones: 1Escola Paulista de Medicina, Divisao de Doencas Infecciosas, Sao Paulo. Brasil
Año:
Periodo: Jun
Volumen: 6
Número: 3
Paginación: 118-123
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Caso clínico, analítico
Resumen en inglés The increasing magnitude of antifungal resistance as well as the advent of new antifungal drugs has generated a renewed interest in fungal susceptibility testing. We used a previously described disk diffusion method to evaluate the susceptibility profile of a large collection of recent clinical Candida spp. isolates against fluconazole. A total of 1,784 yeast isolates were tested, including the following species: Candida albicans (1,036), C. tropicalis (279), C. parapsilosis (202), C. glabrata (119), C. guilliermondii (90), C. krusei (32), C. lusitaniae (7), Candida spp. (14) and other yeasts (5). Susceptibility ranking to fluconazole obtained with all yeasts tested was: C. parapsilosis @ C. tropicalis @ C. guilliermondii > C. glabrata > C. krusei. The majority (94%) of all yeast isolates tested were susceptible to fluconazole. Isolates of C. glabrata and C. krusei exhibited the highest rate of DDS/resistance among all isolates tested but they represented only 9% of all yeasts routinely sent to our lab. Careful periodical surveillance is needed in order to identify any changes in the susceptibility patterns of fluconazole with the increased use of this antifungal agent in Brazilian tertiary care hospitals
Disciplinas: Biología,
Medicina
Palabras clave: Hongos,
Farmacología,
Candida albicans,
Fluconazol,
Resistencia
Keyword: Biology,
Medicine,
Fungi,
Pharmacology,
Candida albicans,
Fluconazole,
Resistance
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