| Revista: | The brazilian journal of infectious diseases |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000291029 |
| ISSN: | 1413-8670 |
| Autores: | Braga, Eduardo Lorens1 Lyra, Andre Castro2 Ney-Oliveira, Fabrizio Nascimento, Lourianne Silva, Adriano3 Brites, Carlos Marbak, Rosicreuza Lyra, Luiz Guilherme Costa4 Ribeiro-Neto, Manuel L5 Asvin Shah, Koonj6 |
| Instituciones: | 1Universidade Federal da Bahia, Servicio de Gastro-Hepatologia, Salvador, Bahia. Brasil 2Hospital Sao Rafael, Servico de Gastro-Hepatologia, Salvador, Bahia. Brasil 3Universidade Federal da Bahia, Servico de Doencas Infecciosas, Salvador, Bahia. Brasil 4Monte Tabor Foundation, Salvador, Bahia. Brasil 5University of Miami, Jackson Memorial Hospital, Miami, Florida. Estados Unidos de América 6University of Texas, Health Science Center, Houston, Texas. Estados Unidos de América |
| Año: | 2006 |
| Periodo: | Feb |
| Volumen: | 10 |
| Número: | 1 |
| Paginación: | 17-21 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Caso clínico |
| Resumen en inglés | Co-infection with hepatitis C virus (HCV) and human immunodeficiency virus (HIV) is increasingly common and affects the clinical course of chronic hepatitis C. Highly active antiretroviral therapy has improved the life expectancy of HIV infected patients, but, by extending survival, it permits the development of HCV cirrhosis. This study tried to evaluate clinical and epidemiological features of patients with chronic hepatitis C co-infected with HIV. We evaluated 134 HCV-infected patients: i) group A - 65 co-infected HCV/HIV patients, ii) group B - 69 mono-infected HCV patients. The impact of HIV infection on HCV liver disease was analyzed using Child's score, ultrasound findings and liver histology. Patients were subjected to HCV genotyping and anti-HBs dosage. Patients mean age was 42.4 years (±9.1) and 97 (72.4%) were males. Injected drug use and homo/bisexual practice were more frequently encountered in the co-infected group: 68.3% and 78.0%, respectively. Antibodies against hepatitis B virus (anti-HBs) were found in only 38.1% of the patients (66.7% group A x 33.3% group B). Ten out of 14 individuals (71.4%) who had liver disease (Child B or C) and 25 out of 34 (73.5%) who showed ultrasound evidence of chronic liver disease were in the co-infection group. HCV genotype-2/3 was more frequently encountered in co-infected patients (36.9% group A vs. 21.8% group B). Conclusions: a) HIV infection seems to adversely affect the clinical course of chronic hepatitis C, b) injected drug use, bi/homosexual practice and genotype-2/3 were m |
| Disciplinas: | Biología, Medicina |
| Palabras clave: | Genética, Inmunología, Virus, Hepatitis C, VIH, Co-infecciones, Evolución clínica, Genotipos |
| Keyword: | Biology, Medicine, Genetics, Immunology, Virus, Hepatitis C, HIV, Co-infections, Clinical evolution, Genotypes |
| Texto completo: | Texto completo (Ver HTML) |
