| Revista: | The brazilian journal of infectious diseases |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000290730 |
| ISSN: | 1413-8670 |
| Autores: | Brites, Carlos1 Straatmann, Andrea Bahia, Fabianna Pedral-Sampaio, Diana |
| Instituciones: | 1Universidade Federal da Bahia, Fundacao de Infectologia, Salvador, Bahia. Brasil |
| Año: | 2002 |
| Periodo: | Dic |
| Volumen: | 6 |
| Número: | 6 |
| Paginación: | 276-280 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Caso clínico, analítico |
| Resumen en inglés | Sulfonamides are drugs extensively used in the management of AIDS patients. However, the use of sulfonamides is often associated with the development of allergic reactions, provoking the substitution of the drug (by another that may be less effective); alternatively attempts are made to desensitize the patient. OBJECTIVE: Compare two drug regimens (full vs. escalating doses) for the oral desensitization of AIDS patients allergic to sulfonamides. MATERIAL AND METHODS: AIDS patients with previous allergic reactions to sulfonamides and requiring prophylaxis against Pneumocistis carinii, central nervous system toxoplasmosis and diarrhea caused by Isospora belli were randomly assigned to a group receiving a routine dose of cothrimoxazole, or another that received escalating doses of an oral suspension of the same drug, initiating with 75mg/day of sulfamethoxazole that was doubled every 48 hours till the full dose was reached, if no allergic reaction occurred. Patients were monitored for at least 6 months after enrollment in the trial. The major end-point was the ability to maintain prophylactic treatment after that period of time. Plasma viral load (PVL) and CD4/CD8 counts were measured at baseline. Liver enzymes and hematological parameters were measured at baseline and after 1, 3 and 6 months. RESULTS: Eighteen patients were enrolled in the study (15 men and 3 women), with ages ranging from 30 to 57 years (mean 39.9). The mean CD4 counts were slightly higher for patients receiving a full dose; there was also a trend towards higher...... |
| Disciplinas: | Medicina |
| Palabras clave: | Farmacología, Inmunología, SIDA, Alergia, Sulfonamidas, Desensibilización oral |
| Keyword: | Medicine, Pharmacology, AIDS, Allergy, Sulfonamides, Oral desensitization, Immunology |
| Texto completo: | Texto completo (Ver HTML) |
