| Revista: | Revista médica de Chile |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000400494 |
| ISSN: | 0034-9887 |
| Autores: | Alarcón, Pedro1 González, Margarita1 Castro, Erica2 |
| Instituciones: | 1Universidad de Concepción, Facultad de Farmacia, Concepción. Chile 2Universidad San Sebastián, Instituto de Políticas Públicas en Salud, Concepción. Chile |
| Año: | 2016 |
| Periodo: | Jul |
| Volumen: | 144 |
| Número: | 7 |
| Paginación: | 910-916 |
| País: | México |
| Idioma: | Español |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico |
| Resumen en inglés | The gastrointestinal tract hosts around 1014 bacterial microorganisms, in a constantly growing density from the stomach to the distal colon. This microbiota is composed by more than 500 species of bacteria, which are quickly acquired after birth, fairly stable during the host’s life, and essential for human homeostasis. These bacteria have important functions, such as stimulating the immune system, protecting the host from invading bacteria and viruses, and improving digestion, especially of complex carbohydrates. Also, the gut microbiota interacts directly with the immune system. However, the interaction of the intestinal epithelium and its microbiota with the immune system has yet to be fully understood. Secretory immunoglobulin A, produced by the plasma cells in Peyer’s patches and in the lamina propria, maintains non-invasive commensal bacteria and neutralize invasive pathogens. Dendritic cells migrate from the lamina propria of the secondary lymphoid organs to regulate gut immunity. They also have a key role maintaining luminal IgA and inducing the growth of regulatory T cells. Dendritic cells supervise the gut microenvironment too, keeping an immunological equilibrium and tolerance. The importance of the gut microbiota in regulating the immune system lies mostly in the homeostasis-or positive equilibrium. Thus, many diseases are a consequence of poor interactions or a loss of this equilibrium |
| Disciplinas: | Medicina |
| Palabras clave: | Gastroenterología, Inmunología, Inmunidad, Intestinos, Microbiota intestinal, Probióticos, Mecanismos de acción, Epitelio intestinal |
| Keyword: | Medicine, Gastroenterology, Immunology, Immunity, Intestines, Intestinal microbiota, Probiotics, Action mechanism, Intestinal epithelium |
| Texto completo: | Texto completo (Ver HTML) |
