| Revista: | Revista médica de Chile |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000421565 |
| ISSN: | 0034-9887 |
| Autores: | Alvarez, Adalucy1 Moncayo, José Ignacio1 Santacruz, Jorge Javier1 Corredor, Luisa Fernanda1 Reinosa, Elizabeth1 Martínez, José William2 Beltrán, Leonardo3 |
| Instituciones: | 1Universidad Tecnológica de Pereira, Facultad de Ciencias de la Salud, Pereira, Risaralda. Colombia 2Universidad Tecnológica de Pereira, Departamento de Medicina Comunitaria, Pereira, Risaralda. Colombia 3Universidad Tecnológica de Pereira, Laboratorio de Genética Médica, Pereira, Risaralda. Colombia |
| Año: | 2009 |
| Periodo: | Oct |
| Volumen: | 137 |
| Número: | 10 |
| Paginación: | 1309-1314 |
| País: | Chile |
| Idioma: | Español |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | Background:Helicobacter pylori antimicrobial resistance ratesdiffer among countries and even between different areas of a country. In Colombia, the mostcommonly used antimicrobials for the treatment of H pylori infection are amoxicillin,clarithromycin and metronidazole.Aim: To determine antimicrobial susceptibility of H pyloristrains isolated in Colombia.Materials and methods: Eighty eight strains of H pylori wereisolated and identified by microbiological methods and confirmed with polymerase chainreaction (PCR). The detection of antimicrobial resistance to amoxicillin, clarithromycin,metronidazole and tetraclycline, was conducted by the Etest method. Mutations in the 23SrDNA, involved in resistance to clarithromycin, were detected using PCR and restrictionfragment lenght polymorphism. Results: Eighty eight and 2.2% of the strains were resistant tometronidazole and clarithromycin, respectively. No isolate was simultaneously resistant toamoxicillin or tetracycline. The two clarithromycin resistant strains were homozygous for theA2143G mutation. No mutations were found in the remaining 86 susceptible strains.Conclusions: The high rate of metronidazole resistance in our population precludes the use ofthis drug for the empirical treatment of H pylori infection |
| Disciplinas: | Medicina, Biología |
| Palabras clave: | Farmacología, Microbiología, Bacterias, Agentes antibacterianos, Helicobacter pylori, Metronidazol |
| Keyword: | Pharmacology, Microbiology, Bacteria, Antibacterial agents, Helicobacter pylori, Metronidazole |
| Texto completo: | Texto completo (Ver PDF) |
