| Revista: | Revista médica de Chile |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000396405 |
| ISSN: | 0034-9887 |
| Autores: | Cabrera, Walter E1 Behets, Geert2 Lamberts, Ludwig2 D'Haese, Patrick2 |
| Instituciones: | 1Universidad Católica Nuestra Señora de la Asunción, Asunción. Paraguay 2University of Amberes, Faculty of Medicine and Life Sciences, Amberes. Bélgica |
| Año: | 2016 |
| Periodo: | Jun |
| Volumen: | 144 |
| Número: | 6 |
| Paginación: | 704-709 |
| País: | Chile |
| Idioma: | Español |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | The role of lead (Pb) as an environmental cause of nephropathy is difficult to ascertain due to the difficulty to determine clinically its exposure. Aim: To assess lead levels and renal function in a group of males working in mechanical workshops. Material and Methods: Blood and urine samples were obtained from 100 mechanical workshop workers aged 38 ± 16 years and 95 non-exposed office clerks aged 37 ± 17 years. Blood lead and creatinine levels were determined. In exposed workers, urinary excretion of intestinal alkaline phosphatases (IAP) and N-acetyl-glucosaminidase (NAG) were measured as early markers of renal failure. Results: Blood lead levels were 66.4 ± 43 and 33.6 ± 18 µg/L among mechanical workshop workers and non-exposed controls, respectively, p < 0.01. The figures for serum creatinine were 0.9 ± 0.1 and 0.9 ± 0.1 respectively, p = NS. Among exposed workers urinary excretion of IAP was 0.47 ± 0.6 U/L and of NAG, 0.92 ± 1.1 U/L. There was a positive correlation between blood lead levels and NAG excretion (r = 0.284) and IAP excretion (r = 0.346). Conclusions: Exposed workers had higher blood lead levels and there was a weak positive association between these levels and the urinary excretion of NAG and IAP |
| Disciplinas: | Medicina |
| Palabras clave: | Diagnóstico, Nefrología, Toxicología, Plomo, Exposición ambiental, Insuficiencia renal crónica (IRC), Biomarcadores, Orina |
| Keyword: | Medicine, Diagnosis, Nephrology, Toxicology, Lead, Environmental exposure, Chronic renal failure (CRF), Biomarkers, Urine |
| Texto completo: | Texto completo (Ver HTML) |
