| Revista: | Revista médica de Chile |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000408510 |
| ISSN: | 0034-9887 |
| Autores: | Quiñones, Luis1 Roco, Angela1 Cayún, Juan P1 Escalante, Paula1 Miranda, Carla1 Varela, Nelson1 Meneses, Francisca2 Gallegos, Bastián2 Zaruma Torres, Fausto3 Lares Asseff, Ismael3 |
| Instituciones: | 1Universidad de Chile, Facultad de Medicina, Santiago de Chile. Chile 2Universidad Santo Tomás, Escuela de Tecnología Médica, Santiago de Chile. Chile 3Instituto Politécnico Nacional, Durango. México |
| Año: | 2017 |
| Periodo: | Abr |
| Volumen: | 145 |
| Número: | 4 |
| Paginación: | 483-500 |
| País: | Chile |
| Idioma: | Español |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico |
| Resumen en inglés | Pharmacogenomics is an emergent field aimed at tailoring pharmacological therapy. Genetic polymorphisms can modify the expression and function of enzymes and proteins involved in drug metabolism, affecting absorption, distribution, biotransformation and excretion as well as the drug-target interaction. Therefore, the presence of allelic variants will classify people as poor, extensive or rapid/ultra rapid metabolizers, modifying drug efficacy and safety. In this work, the state of art in relation to this discipline is presented and the genetic variants of enzymes that are involved in drug pharmacokinetics or pharmacodynamics are described. The effects of these variants on the therapeutic response to drugs used in our country are also discussed |
| Disciplinas: | Medicina |
| Palabras clave: | Farmacología, Genética, Medicina personalizada, Farmacogenómica, Terapia farmacológica, Variantes, Polimorfismo genético, Biotransformación, Farmacodinamia, Biomarcadores |
| Keyword: | Medicine, Pharmacology, Genetics, Personalized medicine, Pharmacogenomics, Pharmacological therapy, Variants, Genetic polymorphism, Biotransformation, Pharmacodynamics, Biomarkers |
| Texto completo: | Texto completo (Ver HTML) |
