| Revista: | Revista do Instituto de Medicina Tropical de Sao Paulo |
| Base de datos: | |
| Número de sistema: | 000547795 |
| ISSN: | 0036-4665 |
| Autores: | Phetsuksiri, Benjawan1 Srisungngam, Sopa1 Rudeeaneksin, Janisara1 Boonchu, Supranee1 Klayut, Wiphat1 Norrarat, Ronnayuth2 Sangkitporn, Somchai1 Kasetjaroen, Yuthichai2 |
| Instituciones: | 1Ministry of Public Health, National Institute of Health, Nonthaburi. Tailandia 2Ministry of Public Health, Department of Disease Control, Bangkok. Tailandia |
| Año: | 2018 |
| Volumen: | 60 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Resumen en inglés | Interferon-gamma (IFN-γ) release assays have improved latent tuberculosis (TB) detection and have been considered promising for the diagnosis of TB disease. However, diagnosis efficacy data is limited in high burden countries. The aim of this study was to determine the diagnostic potential of the QuantiFERON-TB Gold In-Tube (QFT-GIT) test for the diagnosis of active TB in an endemic setting for TB. A cross-sectional study was conducted in a group of 102 Thai patients with clinical symptoms and chest x-ray findings suggesting of active pulmonary TB and a group of 112 healthy adults. Testing was carried out using sputum microscopy, mycobacterial culture and QFT-GIT test. Of these patients, QFT-GIT was positive in 73 (71.57%), negative in 27 (26.47%), and undetermined in 2 (1.96%) cases. Among healthy controls, QFT-GIT was positive in 18 (16.07%), negative in 93 (83.04%), and undetermined in 1 (0.89%) person. Based on TB culture results, the sensitivity of QFTGIT for diagnosing active TB was 84.21% (95% confidence interval (CI); 72.13-92.52). The positive and negative predictive values were 65.75% (95% CI; 59.26-71.70) and 66.67% (95% CI; 49.94-80.04), respectively. The median IFN-γ level in culture-confirmed TB patients was 3.91 compared to 0.03 IU/mL of the healthy group. QFT-GIT appears to be a useful indirect test for TB diagnosis in Thailand and its use is recommended in association with clinical and radiological assessments for identifying active or latent TB. |
| Disciplinas: | Medicina, Medicina |
| Palabras clave: | Farmacología, Microbiología |
| Keyword: | Pharmacology, Microbiology |
| Texto completo: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
