SARS-CoV-2 vaccines–induced thrombotic thrombocytopenia: should we consider immuno-hypersensitivity?



Título del documento: SARS-CoV-2 vaccines–induced thrombotic thrombocytopenia: should we consider immuno-hypersensitivity?
Revista: Revista de saude publica
Base de datos:
Número de sistema: 000535822
ISSN: 0034-8910
Autores: 1
2
Instituciones: 1German Centre for Integrative Biodiversity Rersearch, Alemania
2Bingham University, Department of Biological Sciences, Karu. Nigeria
Año:
Volumen: 55
País: Brasil
Idioma: Inglés
Resumen en inglés The coronavirus disease 2019 (COVID-19) pandemic is significantly causing unprecedented clinical, socioeconomic, and public health challenges globally. The successful global administration of effective, safe and sustainable vaccine(s) is widely believed to be crucial in mitigating as well as preventing COVID-19. However, the rising cases of severe adverse events following immunization (AEFI) with COVID-19 vaccines including thrombosis, thrombocytopenia, and in some instances, death have created serious global concerns and could enormously contribute to vaccine hesitancy. Although the complete underlying pathophysiology and immunopathology of the COVID-19 vaccines related to AEFI, including thrombosis and/or anaphylaxis, are yet to be determined, exploring possible immuno-hypersensitivity could be crucial in the mechanisms associated with these reactions, thereby mitigating their occurrences as well as restoring confidence in vaccine administration for a COVID-19 free world.
Keyword: COVID-19, prevention & control,
SARS-CoV-2, immunology,
COVID-19 Vaccines,
Immunogenicity, Vaccine,
Embolism and Thrombosis
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