| Revista: | Revista de saude publica |
| Base de datos: | |
| Número de sistema: | 000535968 |
| ISSN: | 0034-8910 |
| Autores: | Skaathun, Britt1 Pines, Heather A.1 Patterson, Thomas L2 Semple, Shirley J2 Pekar, Jonathan3 Harvey Vera, Alicia4 Rangel, Gudelia5 Mehta, Sanjay R.1 |
| Instituciones: | 1University of California, Department of Medicine, San Diego. Estados Unidos 2University of California, Department of Psychiatry, San Diego. Estados Unidos 3University of California, Bioinformatics and Systems Biology Program, San Diego. Estados Unidos 4Universidad Xochicalco, Tijuana, Baja California. México 5United States-Mexico Border Health Commission, Tijuana, Baja California. México 6El Colegio de la Frontera Norte, Tijuana, Baja California. México 7University of California, Department of Pathology, San Diego. Estados Unidos 8San Diego Veterans Affairs Medical Center, Department of Medicine, San Diego. Estados Unidos |
| Año: | 2020 |
| Volumen: | 54 |
| País: | Brasil |
| Idioma: | Inglés |
| Resumen en inglés | OBJECTIVE To characterize recent HIV infections among newly diagnosed men who have sex with men and transgender women in Tijuana. METHODS Limiting Antigen (LAg)-Avidity testing was performed to detect recent HIV infection within a cohort of newly-diagnosed men who have sex with men and transgender women in Tijuana. Logistic regression was used to determine characteristics associated with recent infection. A partial transmission network was inferred using HIV-1 pol sequences. Tamura-Nei 93 genetic distances were measured between all pairs of sequences, and the network was constructed by inferring putative transmission links (genetic distances ≤ 1.5%). We assessed whether recent infection was associated with clustering within the inferred network. RESULTS Recent infection was detected in 11% (22/194) of newly-diagnosed participants. Out of the participants with sequence data, 60% (9/15) with recent infection clustered compared with 31% (43/139) with chronic infection. Two recent infections belonged to the same cluster. In adjusted analyses, recent infection was associated with years of residence in Tijuana (OR = 1.5; 95%CI 1.01–1.09), cocaine use (past month) (OR = 8.50; 95%CI 1.99–28.17), and ever experiencing sexual abuse (OR = 2.85; 95%CI 1.03–7.85). DISCUSSION A total of 11% of men newly diagnosed with HIV who have sex with men and transgender women in Tijuana were recently infected. The general lack of clustering between participants with recent infection suggests continued onward HIV transmission rather than an outbreak within a particular cluster. |
| Keyword: | HIV Infections, epidemiology, Sexual and Gender Minorities, Transgender Persons, Disease Transmission, Infectious |
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