| Revista: | Revista de investigación clínica |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000453209 |
| ISSN: | 0034-8376 |
| Autores: | Castro Eguiluz, Denisse1 Barquet Muñoz, Salim A2 Arteaga Gómez, Ana C3 Salcedo Hernández, Rosa A2 Rodríguez Trejo, Amelia4 Gallardo Rincón, Dolores5 Serrano Olvera, Juan A6 Aranda Flores, Carlos7 |
| Instituciones: | 1Instituto Nacional de Cancerología, Departamento de Investigación Clínica, Ciudad de México. México 2Instituto Nacional de Cancerología, Departamento de Ginecología Oncológica, Ciudad de México. México 3Instituto Nacional de Perinatología, Departamento de Ginecología Oncológica, Ciudad de México. México 4Centro Estatal de Cancerología de Nayarit, Departamento de Ginecología Oncológica, Tepic, Nayarit. México 5Instituto Nacional de Cancerología, Departamento de Oncología Médica, Ciudad de México. México 6Centro Médico ABC, Departamento de Oncología Médica, Ciudad de México. México 7Hospital General de México, Departamento de Oncología, Ciudad de México. México |
| Año: | 2020 |
| Periodo: | Jul-Ago |
| Volumen: | 72 |
| Número: | 4 |
| Paginación: | 239-249 |
| País: | México |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | Human papillomavirus (HPV) has been associated with the development of precancerous lesions of the cervix and cervical cancer (CC). Prophylactic HPV vaccination induces the development of a specific memory immune response that facilitates HPV elimination once the natural infection occurs. At present, in addition to the prophylactic vaccine, therapeutic vaccines are being developed and researched with the aim of inducing an immune response that allows the elimination of HPV-infected cells. The purpose of this study is to describe the current evidence on the use of therapeutic vaccines and their effect on cervical precancerous lesions, to establish recommendations on their clinical use. So far, the studies that have generated results have described a marginal beneficial effect of the prophylactic vaccine in the management of infection and pre-invasive lesions. Based on the evidence, continuing research on the efficacy and safety of therapeutic vaccines for the treatment of cervical intraepithelial lesions is recommended. The use of the HPV prophylactic vaccine as treatment for pre-existing lesions is not advised, but it is recommended to prevent new lesions |
| Disciplinas: | Medicina |
| Palabras clave: | Ginecología y obstetricia, Oncología, Profilaxis, Virus del papiloma humano, Lesión precancerosa, Vacunas terapéuticas, Citotoxicidad |
| Keyword: | Gynecology and obstetrics, Oncology, Prophylaxis, Human papillomavirus, Precancerous lesion, Therapeutic vaccines, Cytotoxicity |
| Texto completo: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
