| Revista: | Revista de investigación clínica |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000452929 |
| ISSN: | 0034-8376 |
| Autores: | Inanc, Ibrahim H1 Sabanoglu, Cengiz1 |
| Instituciones: | 1Kirikkale Yüksek İhtisas Hospital, Department of Cardiology, Kirikkale. Turquía |
| Año: | 2022 |
| Periodo: | Sep-Oct |
| Volumen: | 74 |
| Número: | 5 |
| Paginación: | 258-267 |
| País: | México |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | Background: Low-grade inflammation is known to facilitate the development of hypertensive organ damage. The systemic immune-inflammation index (SII) is a new inflammatory index based on circulating immune-inflammatory cells. Objectives: The objectives of this study were to investigate the relationship between the SII and asymptomatic organ damage (AOD) in patients with newly diagnosed treatment-naive hypertension (HTN). Methods: A total of 500 participants (≥ 18 years) were enrolled in the study, including 250 patients and 250 healthy volunteers. Microalbuminuria of > 30 mg/day or proteinuria of > 150 mg/day, left ventricular mass index of > 95 g/m2 in women and > 115 g/m2 in men, and carotid intima-media thickness of > 0.9 mm or the presence of plaque in the carotid were evaluated as AOD indicators. AOD grade was classified as follows: Grade I - One organ involved, Grade II - Two organs involved, Grade III - Three organs involved, and Grade IV - Four organs involved. Results: SII values were higher among patients with HTN than in the control group. Positive correlations were found between the SII and AOD indicators and C-reactive protein levels. Increasing SII values were a common independent predictor of the presence and severity of AOD. The gradually increasing threshold values of the SII from no AOD to Grade III-IV exhibited high diagnostic performance. Conclusions: High SII values were independent predictors of the presence and severity of AOD in patients with newly diagnosed treatment-naive HTN. Considering the role of inflammation in HTN, the SII, which can be easily evaluated using blood parameters, can be an effective prognostic screening tool |
| Disciplinas: | Medicina |
| Palabras clave: | Sistema cardiovascular, Inmunología, Hipertensión, Daño orgánico, Indice de inmunidad-inflamación sistémica |
| Keyword: | Cardiovascular system, Immunology, Hypertension, Organ damage, Systemic immune-inflammation index |
| Texto completo: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
