| Revista: | Revista de investigación clínica |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000452927 |
| ISSN: | 0034-8376 |
| Autores: | Martínez Guerra, Bernardo A1 Medrano Borromeo, Carla2 González Lara, María F1 Román Montes, Carla M1 Tamez Torres, Karla M1 Rajme López, Sandra1 Salgado Guízar, Karla D2 Juárez Menéndez, Noe A2 Ramos Cervantes, Pilar1 Ruiz Palacios, Guillermo M1 Ponce de León, Alfredo1 Sifuentes Osornio, José2 |
| Instituciones: | 1Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Departamento de Enfermedades Infecciosas y Medicina, Ciudad de México. México 2Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Departamento de Medicina, Ciudad de México. México |
| Año: | 2022 |
| Periodo: | Sep-Oct |
| Volumen: | 74 |
| Número: | 5 |
| Paginación: | 268-275 |
| País: | México |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Aplicado, descriptivo |
| Resumen en inglés | Background: Prognostic factors in previously healthy young patients with COVID-19 remained understudied. Objective: The objective of the study was to identify factors associated with in-hospital death or need for invasive mechanical ventilation (IMV) in young (aged ≤ 65 years) and previously healthy patients with COVID-19. Methods: We conducted a prospective cohort study that included patients admitted with COVID-19. The primary outcome was in-hospital death/need for IMV. Secondary outcomes included need for IMV during follow-up, days on IMV, length of stay (LOS), hospital-acquired pneumonia/ventilator-associated pneumonia (HAP/VAP), and pulmonary embolism (PE). Bivariate and multivariate analyses were performed. Results: Among 92 patients, primary outcome occurred in 16 (17%), death in 12 (13%), need for IMV in 16 (17%), HAP/VAP in 7 (8%), and PE in 2 (2%). Median LOS and IMV duration were 7 and 12 days, respectively. Independent associations were found between the primary outcome and male sex (Adjusted odds ratio [aOR] 7.1, 95%CI 1.1-46.0, p < 0.05), D-dimer levels > 1000ng/mL (aOR 9.0, 95%CI 1.6-49.1, p < 0.05), and RT-PCR Ct-value ≤ 24 on initial swab samples (aOR 14.3, 95%CI 2.0-101.5, p < 0.01). Conclusions: In young and non-comorbid COVID-19 patients, male sex, higher levels of D-dimer, and low SARS-CoV-2 RT-PCR Ct-value on an initial nasopharyngeal swab were independently associated with increased in-hospital mortality or need for IMV |
| Disciplinas: | Medicina |
| Palabras clave: | Virus, Diagnóstico, SARS-CoV-2, COVID-19, Reacción en cadena de la polimerasa (PCR), Factores pronósticos, Jóvenes |
| Keyword: | Virus, Diagnosis, SARS-CoV-2, COVID-19, Polymerase chain reaction (PCR), Prognostic factors, Young people |
| Texto completo: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
