Oxidative Stress, Telomere Length, and Frailty in an Old Age Population
Título del documento: Oxidative Stress, Telomere Length, and Frailty in an Old Age Population
Revista: Revista de investigación clínica
Base de datos: PERIÓDICA
Número de sistema: 000454108
ISSN: 0034-8376
Autores: 1
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Instituciones: 1Instituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI, Ciudad de México. México
Año:
Periodo: Nov-Dic
Volumen: 71
Número: 6
Paginación: 393-401
País: México
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Analítico, descriptivo
Resumen en inglés Background A global aging population requires focusing on the risk factors for unhealthy aging, preventive medicine, and chronic disease management. The identification of adverse health outcomes in older adults has been addressed by the characterization of frailty as a biological syndrome. In this field, oxidative stress and telomere length have been suggested as biomarkers of aging Objective The objective of the study was to study the association of oxidative stress, telomere length, and frailty in an old age population Methods We conducted a cross-sectional study based on 2015 data from 202 members of a cohort of older adults (n = 202; F/M gender ratio: 133/69; mean age: 69.89 ± 7.39 years). Reactive oxygen species were measured by dichlorofluorescein diacetate and lipid peroxidation by malondialdehyde. Telomere length was determined using quantitative polymerase chain reaction with SYBR Green Master Mix Results Statistical analysis showed an association between telomere length and frailty but no association between oxidative stress and telomere length or frailty Conclusions Telomere length could eventually be used as a marker to differentiate between healthy and unhealthy aging as expressed by frailty phenotype; oxidative stress seemed merely a biological process of aging
Disciplinas: Medicina
Palabras clave: Geriatría,
Envejecimiento saludable,
Homeostasis,
Fragilidad,
Biomarcadores
Keyword: Geriatrics,
Healthy aging,
Biomarkers,
Homeostasis,
Frailty
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