Methylene Blue for Treatment of Hospitalized COVID-19 Patients: A Randomized, Controlled, Open-Label Clinical Trial, Phase 2



Título del documento: Methylene Blue for Treatment of Hospitalized COVID-19 Patients: A Randomized, Controlled, Open-Label Clinical Trial, Phase 2
Revista: Revista de investigación clínica
Base de datos: PERIÓDICA
Número de sistema: 000453062
ISSN: 0034-8376
Autores: 1
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Instituciones: 1Surgical Oncology Research Center, Mashhad. Irán
2Shariati Hospital, Department of Internal Medicine, Teherán. Irán
3Faculty of Medicine, Department of Anesthesiology, Mashhad. Irán
4Hasheminejad Hospital, Infectious Diseases Ward, Mashhad. Irán
5Lung Diseases Research Center, Mashhad. Irán
6Faculty of Medicine, Kidney Transplantation Complications Research Center, Mashhad. Irán
7School of Medicine, Metabolic Syndrome Research Center, Mashhad. Irán
8Faculty of Medicine, Critical Care Lung Research Center, Mashhad. Irán
9Emamreza Hospital, Department of Internal Medicine, Mashhad. Irán
10Emamreza Hospital, Department of Infectious diseases, Mashhad. Irán
11Ghaem Hospital, Department of Internal Medicine, Karaj. Irán
12Imam Reza Hospital, Clinical Research Development Unit, Mashhad. Irán
13Mashhad University of Medical Sciences, School of Pharmacy, Mashhad. Irán
14Aristotle University of Thessaloniki, Medical School, Thessaloniki, Macedonia. Grecia
Año:
Periodo: May-Jun
Volumen: 73
Número: 3
Paginación: 190-198
País: México
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Experimental, aplicado
Resumen en inglés Background: There is no pharmacological intervention on the treatment of hypoxemia and respiratory distress in COVID-19 patients. Objective: The objective of the study was to study the effect of the reduced form of methylene blue (MB) on the improvement of oxygen saturation (SpO2) and respiratory rate (RR). Methods: In an academic medical center, 80 hospitalized patients with severe COVID-19 were randomly assigned to receive either oral MB along with standard of care (SOC) (MB group, n = 40) or SOC only (SOC group, n=40). The primary outcomes were SpO2 and RR on the 3rd and 5th days. The secondary outcomes were hospital stay and mortality within 28 days. Results: In the MB group, a significant improvement in SpO2 and RR was observed on the 3rd day (for both, p < 0.0001) and also the 5th day (for both, p < 0.0001). In the SOC group, there was no significant improvement in SpO2 (p = 0.24) and RR (p = 0.20) on the 3rd day, although there was a significant improvement of SpO2 (p = 0.002) and RR (p = 0.01) on the 5th day. In the MB group in comparison to the SOC group, the rate ratio of increased SpO2 was 13.5 and 2.1 times on the 3rd and 5th days, respectively. In the MB group compared with the SOC group, the rate ratio of RR improvement was 10.1 and 3.7 times on the 3rd and 5th days, respectively. The hospital stay was significantly shortened in the MB group (p = 0.004), and the mortality was 12.5% and 22.5% in the MB and SOC groups, respectively. Conclusions: The addition of MB to the treatment protocols significantly improved SpO2 and respiratory distress in COVID-19 patients, which resulted in decreased hospital stay and mortality. ClinicalTrials.gov: NCT04370288
Disciplinas: Medicina
Palabras clave: Neumología,
Terapéutica y rehabilitación,
COVID-19,
Hipoxemia,
Azul de metileno,
Mortalidad
Keyword: Pneumology,
Therapeutics and rehabilitation,
COVID-19,
Methylene Blue,
Hypoxemia,
Mortality
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