| Revista: | Revista de investigación clínica |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000452964 |
| ISSN: | 0034-8376 |
| Autores: | Galnares Olalde, Javier A1 López Hernández, Juan C1 García Grimshaw, Miguel2 Valdés Ferrer, Sergio I2 Briseño Godínez, María E1 de Sarachaga, Adib J1 Alegría Loyola, Marco A4 Bazán Rodriguez, Anna1 Martínez Jiménez, Eunice1 Vargas Cañas, Edwin S1 |
| Instituciones: | 1Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Departamento de Enfermedades Neuromusculares, Ciudad de México. México 2Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Departamento de Neurología y Psiquiatría, Ciudad de México. México 3Centro Médico ABC, Departamento de Neurología, Ciudad de México. México |
| Año: | 2022 |
| Periodo: | May-Jun |
| Volumen: | 74 |
| Número: | 3 |
| Paginación: | 121-130 |
| País: | México |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | Guillain-Barré syndrome (GBS) is the most frequent cause of acute flaccid paralysis and if not diagnosed and treated timely, a significant cause of long-term disability. Incidence in Latin America ranges from 0.71 to 7.63 cases/100,000 person-years. Historically, GBS has been linked to infections (mainly gastrointestinal by Campylobacter jejuni) and vaccines (including those against severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]); however, a trigger cannot be detected in most cases. Regarding SARS-CoV-2, epidemiological studies have found no association with its development. Acute motor axonal neuropathy is the most common electrophysiological variant in Mexico and Asian countries. Intravenous immunoglobulin or plasma exchanges are still the treatment cornerstones. Mortality in Mexico can be as high as 12%. Advances in understanding the drivers of nerve injury in GBS that may provide the basis for developing targeted therapies have been made during the past decade; despite them, accurate criteria for selecting patients requiring acute treatment, prognostic biomarkers, and novel therapies are still needed. The newly-developed vaccines against SARS-CoV-2 have raised concerns regarding the potential risk for developing GBS. In the midst of coronavirus disease 2019 and vaccination campaigns against SARS-CoV-2, this review discusses the epidemiology, clinical presentation, management, and outcomes of GBS in Mexico |
| Disciplinas: | Medicina |
| Palabras clave: | Neurología, Inmunología, Síndrome de Guillain-Barré, Polineuropatías, Inmunoglobulina intravenosa, Intercambio plasmático, Parálisis flácida arrefléxica, Anticuerpos antigangliósidos |
| Keyword: | Neurology, Immunology, Guillain-Barré syndrome, Polyneuropathy, Intravenous immunoglobulin, Plasma exchange, Areflexic flaccid paralysis, Anti-ganglioside antibodies |
| Texto completo: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
