| Revista: | Revista de investigación clínica |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000456870 |
| ISSN: | 0034-8376 |
| Autores: | Pérez Lohman, Christian1 Kerik, Nora E2 Díaz Meneses, Iván E2 Cervantes Arriaga, Amin3 Rodríguez Violante, Mayela1 |
| Instituciones: | 1Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Clínica de Trastornos del Movimiento, Ciudad de México. México 2Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Unidad de Imagen Molecular PET-CT, Ciudad de México. México 3Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Unidad de Investigación Clínica en Enfermedades Neurodegenerativas, Ciudad de México. México |
| Año: | 2018 |
| Volumen: | 70 |
| Número: | 6 |
| Paginación: | 285-290 |
| País: | México |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | The use of single-photon emission computed tomography and positron emission tomography (PET) has proven to be helpful in differentiating Parkinson’s disease (PD) from other movement disorders with a sensitivity of up to 95%. Objective: The objective of this study was to determine the accuracy of [11C]DTBZ PET imaging in patients with clinically uncertain parkinsonism from a tertiary referral center in Mexico City. Materials and Methods: Patients who underwent [11C]DTBZ PET brain scan due to clinically uncertain parkinsonism where divided into two groups: PD or non-PD. A scan was considered positive when visual assessment revealed a decrease in [11C]DTBZ uptake typical for PD; a scan was considered negative when visual assessment showed no decrease in [11C]DTBZ uptake or showed a decrease in tracer uptake in a non-PD pattern. Sensitivity, specificity, and positive and negative predictive values were calculated using a 2 × 2 table, with a 95% confidence interval. Results: A total of 39 patients were included in the study. 14 PET studies were deemed positive and 25 PET studies were deemed negative; 12 true positives and 23 true negatives were found. This yielded a sensitivity of 92.9% (95% CI, 66.1-99.8), specificity of 92% (95% CI, 74-99), PPV of 86.7% (95% CI, 63.1-96.1), and NPV of 95.8% (95% CI, 79.1-98.4). Conclusions: The [11C]DTBZ PET has an excellent accuracy for differentiating idiopathic PD from other disorders |
| Disciplinas: | Medicina |
| Palabras clave: | Neurología, Diagnóstico, Enfermedad de Parkinson, Diagnóstico diferencial, Tomografía por emisión de positrones |
| Keyword: | Neurology, Diagnosis, Parkinson disease, Differential diagnosis, Positron emission tomography |
| Texto completo: | https://www.medigraphic.com/pdfs/revinvcli/nn-2018/nn186d.pdf |
