Comparison of Sublingual and Intramuscular Administration of Vitamin B12 for the Treatment of Vitamin B12 Deficiency in Children



Título del documento: Comparison of Sublingual and Intramuscular Administration of Vitamin B12 for the Treatment of Vitamin B12 Deficiency in Children
Revista: Revista de investigación clínica
Base de datos: PERIÓDICA
Número de sistema: 000453188
ISSN: 0034-8376
Autores: 1
2
Instituciones: 1Ankara University, Faculty of Medicine, Ankara. Turquía
2Kütahya Parkhayat Hospital, Department of Pediatrics, Kutahya Tavsanli. Turquía
Año:
Periodo: Nov-Dic
Volumen: 72
Número: 6
Paginación: 380-385
País: México
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Analítico, descriptivo
Resumen en inglés Background: In most countries, contrary to some disadvantages, such as pain, relatively higher cost, and poor adherence to treatment, intramuscular (IM) route is still the primary treatment method for Vitamin B12 (VB12) deficiency. In recent years, because of these difficulties, new treatment methods are being sought for VB12 deficiency. Objectives: We aimed to compare sublingual (SL) and IM routes of VB12 administration in children with VB12 deficiency and to compare the efficacy of methylcobalamin and cyanocobalamin therapy in these children. Methods: This retrospective study comprised 129 patients with VB12 deficiency (serum Vitamin 12 level ≤ 200 pg/mL) aged 5-18 years. Based on the formulations of Vitamin 12, we divided the patients into three treatment groups as IM cyanocobalamin, SL cyanocobalamin, and SL methylcobalamin. Results: After Vitamin 12 therapy, serum Vitamin 12 levels increased significantly in all patients, and there was a statistically significant difference between the treatment groups (p < 0.05). Conclusions: SL cyanocobalamin and methylcobalamin were found as effective as IM cyanocobalamin for children with Vitamin 12 deficiency in correcting serum Vitamin 12 level and hematologic abnormalities
Disciplinas: Medicina
Palabras clave: Pediatría,
Farmacología,
Deficiencia vitamínica,
Cianocobalamina,
Vitamina B12,
Vías de administración
Keyword: Pediatrics,
Pharmacology,
Vitamin deficiency,
Cyanocobalamin,
Vitamin B12,
Administration routes
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