| Revista: | Revista de investigación clínica |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000455299 |
| ISSN: | 0034-8376 |
| Autores: | Cid Juárez, Silvia1 Téllez Navarrete, Norma A1 Bautista Bernal, Anaid1 León Gómez, Pablo1 Salas Escamilla, Isabel1 Gochicoa Rangel, Laura1 Pérez Padilla, Rogelio1 |
| Instituciones: | 1Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Ciudad de México. México |
| Año: | 2023 |
| Periodo: | Ene-Feb |
| Volumen: | 75 |
| Número: | 1 |
| Paginación: | 29-36 |
| País: | México |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Aplicado, descriptivo |
| Resumen en inglés | Background The values of arterial blood gases (ABG) change with altitude above sea level; empirical verification is essential because ventilatory acclimatization varies with ethnicity and a population's adaptation. Objective The aim of the study was to describe ABG in a healthy population residing at 2,240 meters above sea level, to identify the mean level of alveolar ventilation (PaCO2), and to know whether a progressive increase in PaCO2 occurs with age and the impact of increasing body mass index (BMI). Methods We conducted a cross-sectional study in a referral center for respiratory diseases in Mexico City. Associations among variables with correlation coefficient and regression models of PaO2, SaO2, and P(A-a)O2 as dependent variables as a function of age, BMI, minute ventilation, or breathing frequency were explored. Results Two hundred and seventeen healthy subjects were evaluated with a mean age of 40 ± 15 years, mean of the PaO2 was 71 ± 6 mmHg, SaO2 94% ± 1.6%, PaCO2 30.2 ± 3.4 mmHg, HCO3 20 ± 2 mmol/L, BE-2.9 ± 1.9 mmol/L, and the value of pH was 7.43 ± 0.02. In a linear regression, the main results were PaO2 = 77.5-0.16*age (p < 0.0001) and with aging P(A-a)O2 tended to increase 0.12 mmHg/year. PaCO2 in women increased with age by 0.075 mmHg/year (p = 0.0012, PaCO2 =26.3 + 0.075*age). SaO2 and PaO2 decreased significantly in women with higher BMI 0.14% and 0.52 mmHg per kg/m2, (p = 0.004 and 0.002 respectively). Conclusion Mean PaCO2 was 30.7 mmHg, implying a mean alveolar ventilation of around 30% above that at sea level |
| Disciplinas: | Medicina |
| Palabras clave: | Fisiología humana, Oxigenación, Hiperventilación, Gases sanguíneos, Altura |
| Keyword: | Human physiology, Oxygenation, Hyperventilation, Arterial blood gases, Altitude |
| Texto completo: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
