| Revista: | Revista de investigación clínica |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000452979 |
| ISSN: | 0034-8376 |
| Autores: | Eyyupkoca, Ferhat1 Yildirim, Onur1 Sivri, Serkan2 Ali Felekoglu, Mehmet3 Demirtas, Bekir4 Sait Altintas, Mehmet5 Ugurlu Ilgin, Burcu6 Faruk Ates, Omer7 |
| Instituciones: | 1Dr. Nafiz Korez Sincan State Hospital, Department of Cardiology, Ankara. Turquía 2Yildirim Beyazit University, Ataturk Training and Research Hospital, Ankara. Turquía 3Ankara Diskapi Training and Research Hospital, Department of Cardiology, Ankara. Turquía 4Ankara Numune Training and Research Hospital, Department of Cardiology, Ankara. Turquía 5Yedikule Chest Diseases and Thoracic Surgery Training and Research Hospital, Department of Cardiology, Estambul. Turquía 6Ankara Numune Training and Research Hospital, Department of Cardiology, Ankara. Turquía 7Yildirim Beyazit University, Ataturk Training and Research Hospital, Ankara. Turquía |
| Año: | 2022 |
| Periodo: | Mar-Abr |
| Volumen: | 74 |
| Número: | 2 |
| Paginación: | 104-112 |
| País: | México |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | Background: Inflammation plays a critical role in cardiac remodeling after myocardial infarction (MI). Monocyte to high-density lipoprotein-cholesterol (HDL-C) ratio (MHR) has emerged as a potential indicator of inflammation. Objectives: The study aimed to investigate the prognostic role of MHR at the time of hospital admission in late cardiac remodeling and subsequent 1-year mortality in an academic training and research hospital. Methods: This prospective multicenter study included 231 patients with acute ST-elevation MI. Left ventricular (LV) functions and volumes were assessed by cardiac magnetic resonance (CMR) imaging at 2 weeks and 6 months post-MI. The definition of adverse cardiac remodeling (AR) was based on the increase of LV end-diastolic volume by ≥ 12% at 6 months post-MI. All patients were followed for survival for 1 year after the second CMR imaging measurements. Results: At 6 months post-MI, 20 patients (23.8%) exhibited AR. The median MHR was higher in the AR group compared to the group without AR (2.2 vs. 1.5, p < 0.001). A positive correlation was found between MHR and infarct size in the groups with and without AR. High MHR was an independent predictor of AR (OR: 3.21, p = 0.002). The cut-off value of MHR in predicting AR was found to be >1.6 with 92.7% sensitivity and 70.1% specificity (AUC ± SE: 0.839 ± 0.03, p < 0.001). Mortality risk was 5.62-fold higher in the group with MHR of >1.6 (HR: 5.62, p < 0.001). Conclusions: These results indicate that admission MHR is a useful tool to predict patients with AR who are at risk of progression to heart failure and mortality after MI |
| Disciplinas: | Medicina |
| Palabras clave: | Sistema cardiovascular, Diagnóstico, Infarto al miocardio, Remodelación cardiaca, Relación monocito-Lipoproteína de alta densidad, Biomarcadores, Inflamación |
| Keyword: | Cardiovascular system, Diagnosis, Myocardial infarction, Biomarker, Cardiac remodeling, Monocyte to high-density lipoprotein ratio, Inflammation |
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