Superdisintegrant Selection for Tramadol Dispersible Tablets



Título del documento: Superdisintegrant Selection for Tramadol Dispersible Tablets
Revista: Revista de ciencias farmaceuticas basica e aplicada
Base de datos: PERIÓDICA
Número de sistema: 000359047
ISSN: 1808-4532
Autores: 1
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1
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Instituciones: 1MAEER’s Maharashtra Institute of Pharmacy, Department of Pharmaceutics, Pune, Maharashtra. India
Año:
Periodo: Sep-Dic
Volumen: 31
Número: 3
Paginación: 251-257
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Experimental
Resumen en inglés The selection of a suitable superdisintegrant for a rapidly disintegrating dosage form is of the utmost importance, since disintegration time (DT) is a critical parameter. An experimental design was implemented, to find out the effects of superdisintegrants (sodium starch glycolate, crospovidone, croscarmellose sodium and methacrylic copolymer with divinyl benzene), at 2, 4, 6% w/w, on tablet hardness, with respect to DT. Methacrylic copolymer with divinyl benzene (at 4 wt%) was selected as the best superdisintegrant, adequate for the formulation of dispersible Tramadol tablets. With increasing hardness, there was a considerable increase in DT at all concentrations of superdisintegrants. A combination of crospovidone and methacrylic copolymer with divinyl benzene showed a remarkable drop in DT to 0.33 min. The stability of the batch with lowest DT was also tested under various conditions and the results suggested that there was no degradation over the test period
Disciplinas: Química
Palabras clave: Química farmacéutica,
Tramadol,
Almidón glicolato de sodio,
Crospovidona,
Croscarmelosa de sodio,
Superdisgregantes
Keyword: Chemistry,
Medicinal chemistry,
Tramadol,
Sodium Starch Glycolate,
Crospovidone,
Croscarmellose Sodium,
Superdisintegrants
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