| Revista: | Revista brasileira de hematologia e hemoterapia |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000306045 |
| ISSN: | 1516-8484 |
| Autores: | Chinelato-Fernandes, Ana R1 Bonini-Domingos, Claudia R |
| Instituciones: | 1Universidade Estadual Paulista "Julio de Mesquita Filho", Instituto de Biociencias, Sao Paulo. Brasil |
| Año: | 2005 |
| Periodo: | Jul-Sep |
| Volumen: | 27 |
| Número: | 3 |
| Paginación: | 208-210 |
| País: | Brasil |
| Idioma: | Portugués |
| Tipo de documento: | Correspondencia |
| Enfoque: | Descriptivo |
| Resumen en inglés | Over 900 hemoglobin variants have already been described, with more than 100 having electrophoretic migration similar to Hb S in alkaline pHs. In the analysis of 98 samples that presented with this migration pattern, Hb D-Los Angeles in heterozygosis was prevalent and associations with Hb S and Hb Lepore were identified, a previously unpublished fact and with beta-thalassemia, which is also rare. In addition, carriers of Hb Korle-Bu and Hb Hasharon were found amongst other hemoglobinopathies. This heterogeneity reflects the special colonization conditions and the high racial admixture in Brazil. The correct laboratorial diagnosis is very important for hemoglobinopathy carriers because of the many associations of hemoglobin alterations and the variants with co-migration. An accurate identification of hemoglobin variants is essential for genetic counseling and appropriate therapy |
| Disciplinas: | Medicina |
| Palabras clave: | Hematología, Genética, Hemoglobina, Diversidad genética, Brasil |
| Keyword: | Medicine, Hematology, Genetics, Hemoglobin, Genetic diversity, Brazil |
| Texto completo: | Texto completo (Ver HTML) |
