Sistema antioxidante envolvendo o ciclo metabólico da glutationa associado a metodos eletroanaliticos na avaliacao do estresse oxidativo



Título del documento: Sistema antioxidante envolvendo o ciclo metabólico da glutationa associado a metodos eletroanaliticos na avaliacao do estresse oxidativo
Revista: Quimica nova
Base de datos: PERIÓDICA
Número de sistema: 000196062
ISSN: 0100-4042
Autores: 1


Instituciones: 1Universidade Estadual de Campinas, Faculdade de Ciencias Medicas, Campinas, Sao Paulo. Brasil
2Universidade Estadual de Campinas, Instituto de Quimica, Campinas, Sao Paulo. Brasil
Año:
Periodo: Ene-Feb
Volumen: 24
Número: 1
Paginación: 112-119
País: Brasil
Idioma: Portugués
Tipo de documento: Artículo
Enfoque: Teórico, divulgación
Resumen en inglés The most relevant advances on the analytical applications of glutathione determination based on glutathione redox cycle and the antioxidant system are given. The main enzymes that participate of the glutathione metabolism are the glutathione peroxidase and glutathione reductase. The glutathione peroxidase has a major role in the removal of hydrogen peroxide and lipid peroxides from the cells. These enzymes, operating in tandem with catalase and superoxide dismutase promote a scavenging of oxyradical products in tissues minimizing damages caused by these species. Reduced glutathione is the major intracellular thiol found in mammals and changes in the glutathione concentration in biological fluids or tissues may provide a useful marker in certain disorders like hemolytic anemia, myocardial oxidative stress and in the investigation of some kinds of cancers. Particular attention is devoted to the main advantages supplied by biosensors in which there is an incorporation of bioactive materials for the glutathione determination. The correlation between stability and sensitivity of some reduced glutathione electrochemical sensors is discussed
Disciplinas: Química
Palabras clave: Bioquímica,
Química analítica,
Glutatión,
Estrés oxidativo,
Electroanálisis,
Enzimas,
Glutatión peroxidasa,
Glutatión reductasa,
Ciclos metabólicos
Keyword: Chemistry,
Analytical chemistry,
Biochemistry,
Glutathione,
Oxidative stress,
Electroanalysis,
Enzymes,
Glutathione peroxidase,
Glutathione reductase,
Metabolic cycles
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