The gene expression of Leishmania infantum chagasi inside Lutzomyia longipalpis, the main vector of visceral leishmaniasis in Brazil
Título del documento: The gene expression of Leishmania infantum chagasi inside Lutzomyia longipalpis, the main vector of visceral leishmaniasis in Brazil
Revista: Memorias do Instituto Oswaldo Cruz
Base de datos: PERIÓDICA
Número de sistema: 000446431
ISSN: 0074-0276
Autores: 1
1
1
Instituciones: 1Fundacao Oswaldo Cruz, Instituto Oswaldo Cruz, Rio de Janeiro. Brasil
Año:
Volumen: 116
País: Brasil
Idioma: Inglés
Tipo de documento: Nota breve o noticia
Enfoque: Aplicado, descriptivo
Resumen en inglés Leishmania infantum chagasi is the causative agent and Lutzomyia longipalpis is the main vector of visceral leishmaniasis in the Americas. We investigated the expression of Leishmania genes within L. longipalpis after artificial infection. mRNAs from genes involved in sugar and amino acid metabolism were upregulated at times of high parasite proliferation inside the insect. mRNAs from genes involved in metacyclogenesis had higher expression in late stages of infection. Other modulated genes of interest were involved in immunomodulation, purine salvage pathway and protein recycling. These data reveal aspects of the adaptation of the parasite to the microenvironment of the vector gut and reflect the preparation for infection in the vertebrate
Disciplinas: Medicina,
Biología
Palabras clave: Insectos,
Protozoarios,
Parasitología,
Leishmaniasis visceral,
Vectores biológicos,
Mecanismos de infección,
Leishmania infantum chagasi,
Lutzomyia longipalpis
Keyword: Insects,
Protozoa,
Parasitology,
Visceral leishmaniasis,
Biological vectors,
Infection mechanisms,
Leishmania infantum chagasi,
Lutzomyia longipalpis
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