| Revista: | Memorias do Instituto Oswaldo Cruz |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000452374 |
| ISSN: | 0074-0276 |
| Autores: | Mata Somarribas, Carlos1 Quesada López, José2 Matamoros, María F3 Cervantes Gómez, César4 Mejía, Annia5 Chacón, Karen6 Bendig, Ivannia7 Campos, Roger8 Quesada Morera, Raphael9 Cantanhêde, Lilian Motta10 Pereira, Luiza de Oliveira R10 Cupolillo, Elisa10 |
| Instituciones: | 1Instituto Costarricense de Investigación y Enseñanza en Nutrición y Salud, Centro Nacional de Referencia de Parasitología, Cartago. Costa Rica 2Caja Costarricense del Seguro Social, Area de Salud Santa Rosa de Pocosol, Alajuela. Costa Rica 3Caja Costarricense del Seguro Social, Hospital Escalante Pradilla, San José. Costa Rica 4Caja Costarricense del Seguro Social, Hospital William Allen, Cartago. Costa Rica 5Caja Costarricense del Seguro Social, Area de Salud Florencia, Alajuela. Costa Rica 6Caja Costarricense del Seguro Social, Hospital Ciudad Neily, Puntarenas. Costa Rica 7Caja Costarricense del Seguro Social, Hospital de Guápiles, Limón. Costa Rica 8Caja Costarricense del Seguro Social, Area de Salud Matina, Limón. Costa Rica 9Caja Costarricense del Seguro Social, Area de Salud Talamanca, Limón. Costa Rica 10Fundacao Oswaldo Cruz, Instituto Oswaldo Cruz, Rio de Janeiro. Brasil |
| Año: | 2022 |
| Volumen: | 117 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | Costa Rica has a history of neglecting prevention, control and research of leishmaniasis, including limited understanding on Leishmania species causing human disease across the country and a complete lack of knowledge on the Leishmania RNA virus, described as a factor linked to the worsening and metastasis of leishmanial lesions. OBJECTIVES The aim of this work was to describe a case of cutaneous leishmaniasis by Leishmania (Viannia) guyanensis, bearing infection with Leishmaniavirus 1 (LRV1) in Costa Rica, raising the suspicion of imported parasites in the region. METHODS The Leishmania strain was previously identified by routine hsp70 polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in Costa Rica and subsequently characterised by isoenzyme electrophoresis and Sanger sequencing in Brazil. Screening for LRV1 was conducted with a dual RT-PCR approach and sequencing of the fragment obtained. FINDINGS Since 2016 Costa Rica performs Leishmania isolation and typing as part of its epidemiological surveillance activities. Amongst 113 strains typed until 2019, only one was characterised as a L. (V.) guyanensis, corresponding to the first confirmed report of this species in the country. Interestingly, the same strain tested positive for LRV1. Sequencing of the viral orf1 and 2, clustered this sample with other LRV1 genotypes of South American origin, from the Northeast of Brazil and French Guiana. MAIN CONCLUSION The unique characteristics of this finding raised the suspicion that it was not an autochthonous strain. Notwithstanding its presumed origin, this report points to the occurrence of said endosymbiont in Central American Leishmania strains. The possibility of its local dispersion represents one more challenge faced by regional health authorities in preventing and controlling leishmaniasis |
| Disciplinas: | Medicina |
| Palabras clave: | Virus, Epidemiología, Leishmaniasis, Leishmaniavirus, Nuevos registros, Leishmania guyanensis, Costa Rica |
| Keyword: | Virus, Epidemiology, Leishmaniavirus, Leishmaniasis, New records, Leishmania guyanensis, Costa Rica |
| Texto completo: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
