| Revista: | Memorias do Instituto Oswaldo Cruz |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000452373 |
| ISSN: | 0074-0276 |
| Autores: | Penna, Patricia Sola1 Pitta, Izabela Jardim Rodrigues1 Vital, Robson Teixeira3 Hacker, Mariana Andrea Vilas Boas2 Salles, Ana Maria2 Pinheiro, Roberta Olmo2 Antunes, Sergio Luiz Gomes2 Sarno, Euzenir Nunes2 Jardim, Márcia Rodrigues1 |
| Instituciones: | 1Universidade Federal do Estado do Rio de Janeiro, Programa de Pos-Graduacao em Neurologia, Rio de Janeiro. Brasil 2Fundacao Oswaldo Cruz, Instituto Oswaldo Cruz, Rio de Janeiro. Brasil 3Universidade do Estado do Rio de Janeiro, Rio de Janeiro. Brasil |
| Año: | 2022 |
| Volumen: | 117 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | BACKGROUND The lepromatous pole is a stigmatising prototype for patients with leprosy. Generally, these patients have little or no symptoms of peripheral nerve involvement at the time of their diagnosis. However, signs of advanced peripheral neuropathy would be visible during the initial neurological evaluation and could worsen during and after multidrug therapy (MDT). Disabilities caused by peripheral nerve injuries greatly affect these patients’ lives, and the pathophysiological mechanisms underlying nerve damage remain unclear. OBJECTIVES To evaluate the outcome of peripheral neuropathy in patients with lepromatous leprosy (LL) and persistent neuropathic symptoms years after completing MDT. METHODS We evaluated the medical records of 14 patients with LL who underwent nerve biopsies due to worsening neuropathy at least four years after MDT. FINDINGS Neuropathic pain developed in 64.3% of the patients, and a neurological examination showed that most patients had alterations in the medium- and large-caliber fibers at the beginning of treatment. Neurological symptoms and signs deteriorated despite complete MDT and prednisone or thalidomide use for years. Nerve conduction studies showed that sensory nerves were the most affected. MAIN CONCLUSIONS Patients with LL can develop progressive peripheral neuropathy, which continues to develop even when they are on long-term anti-inflammatory and immunosuppressive therapy |
| Disciplinas: | Medicina |
| Palabras clave: | Dermatología, Neurología, Lepra lepromatosa, Neuropatía periférica, Fisiopatología, Terapia farmacológica |
| Keyword: | Dermatology, Neurology, Lepromatous leprosy, Peripheral neuropathy, Pathophysiology, Pharmacotherapy |
| Texto completo: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
