Evaluation of the impact of serogroup C meningococcal disease vaccination program in Brazil and its regions: a population-based study, 2001-2013
Título del documento: Evaluation of the impact of serogroup C meningococcal disease vaccination program in Brazil and its regions: a population-based study, 2001-2013
Revista: Memorias do Instituto Oswaldo Cruz
Base de datos: PERIÓDICA
Número de sistema: 000405455
ISSN: 0074-0276
Autores: 1
2
3
1
Instituciones: 1Universidade de Brasilia, Faculdade de Medicina, Brasilia, Distrito Federal. Brasil
2Santa Casa de Misericordia de Sao Paulo, Faculdade de Ciencias Medicas, Sao Paulo. Brasil
3Universidade de Brasilia, Faculdade de Ciencias da Saude, Brasilia, Distrito Federal. Brasil
Año:
Periodo: Abr
Volumen: 112
Número: 4
Paginación: 237-246
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Experimental, aplicado
Resumen en inglés Meningococcal C conjugate (MenC) vaccine was introduced as part of the Brazilian National Immunisation Program in 2010 for children < 1 year of age. OBJECTIVES The study objective was to evaluate the impact of this vaccination strategy. METHODS An observational, mixed ecological and analytical study was conducted, based on time series panel data from surveillance records (2001-2013). FINDINGS A total of 37,538 of meningococcal disease cases were recorded during the study period. Of these, 19,997 were attributed to serogroup C. A decrease in meningococcal disease serogroup C (MDC) incidence among children aged < 1 year [65.2%; 95% confidence interval (CI): 20.5-84.7%] and 1-4 years (46.9%; 95%CI: 14.6-79.1%) were found in the three years following vaccination introduction. Vaccination impact on the reduction of MDC incidence varied from 83.7% (95%CI: 51.1-100.0%) in the Midwest region to 56.7% (95%CI: 37.4-76.0%) in the Northeast region. MAIN CONCLUSIONS Vaccination against MDC in Brazil had a positive impact on the population of children aged < 1 year, across all regions, and on the 1-4 year-old cohort. Nevertheless, in our view there is scope for improving the vaccination strategy adopted in Brazil
Disciplinas: Medicina
Palabras clave: Inmunología,
Enfermedad meningocócica,
Vacunación,
Vacunas conjugadas,
Serogrupos,
Epidemiología,
Neisseria meningitidis
Keyword: Medicine,
Immunology,
Meningococcal disease,
Vaccination,
Conjugated vaccines,
Serogroups,
Epidemiology,
Neisseria meningitidis
Texto completo: Texto completo (Ver HTML)