| Revista: | Memorias do Instituto Oswaldo Cruz |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000353098 |
| ISSN: | 0074-0276 |
| Autores: | Pereira, Gabriela Andrade1 Pimenta, Fabricia Pires1 Santos, Fatima Rejane Wink dos2 Damasco, Paulo Vieira3 Hirata-Junior, Raphael1 Mattos-Guaraldi, Ana Luiza1 |
| Instituciones: | 1Universidade do Estado do Rio de Janeiro, Faculdade de Ciencias Medicas, Rio de Janeiro. Brasil 2Universidade Federal do Rio de Janeiro, Instituto de Microbiologia "Paulo de Goes", Rio de Janeiro. Brasil 3Laboratorio Central Noel Nutels, Servico de Bacteriologia, Rio de Janeiro. Brasil |
| Año: | 2008 |
| Periodo: | Ago |
| Volumen: | 103 |
| Número: | 5 |
| Paginación: | 507-510 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | The increasing problems with multidrug resistance in relation to Corynebacterium, including C. diphtheriae, are examples of challenges confronting many countries. For this reason, Brazilian C. diphtheriae strains were evaluated by the E-Test for their susceptibility to nine antibacterial drugs used in therapy. Resistance (MIC < 0.002; 0.38 µg/ml) to penicillin G was found in 14.8% of the strains tested. Although erythromycin (MIC90 0.75 µg/ml) and azithromycin (MIC90 0.064 µg/ml) were active against C. diphtheriae in this study, 4.2% of the strains showed decreased susceptibility (MIC 1.0 µg/ml) to erythromycin. Multiple resistance profiles were determined by the disk diffusion method using 31 antibiotics. Most C. diphtheriae strains (95.74%) showed resistance to mupirocin, aztreonam, ceftazidime, and/or oxacillin, ampicillin, penicillin, tetracycline, clindamycin, lincomycin, and erythromycin. This study presents the antimicrobial susceptibility profiles of Brazilian C. diphtheriae isolates. The data are of value to practitioners, and suggest that some concern exists regarding the use of penicillin |
| Disciplinas: | Medicina |
| Palabras clave: | Farmacología, Microbiología, Difteria, Resistencia a antibióticos, Penicilina, Corynebacterium diphtheriae |
| Keyword: | Medicine, Microbiology, Pharmacology, Diphtheria, Antibiotic resistance, Penicillin, Corynebacterium diphtheriae |
| Texto completo: | Texto completo (Ver HTML) |
