| Revista: | Memorias do Instituto Oswaldo Cruz |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000452424 |
| ISSN: | 0074-0276 |
| Autores: | Monte-Neto, Rubens Lima do1 Moreira, Paulo Otávio Lourenço1 Sousa, Alessandra Mara de1 Garcia, Miguel Antonio do Nascimento2 Maran, Suellen Rodrigues2 Moretti, Nilmar Silvio2 |
| Instituciones: | 1Fundacao Oswaldo Cruz, Instituto Rene Rachou, Belo Horizonte, Minas Gerais. Brasil 2Universidade Federal de Sao Paulo, Departamento de Microbiología, Imunologia e Parasitologia, Sao Paulo. Brasil |
| Año: | 2022 |
| Volumen: | 117 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, prospectivo |
| Resumen en inglés | Despite the increasing number of manuscripts describing potential alternative antileishmanial compounds, little is advancing on translating these knowledges to new products to treat leishmaniasis. This is in part due to the lack of standardisations during pre-clinical drug discovery stage and also depends on the alignment of goals among universities/research centers, government and pharmaceutical industry. Inspired or not by drug repurposing, metal-based antileishmanial drugs represent a class that deserves more attention on its use for leishmaniasis chemotherapy. Together with new chemical entities, progresses have been made on the knowledge of parasite-specific drug targets specially after using CRISPR/Cas system for functional studies. In this regard, Leishmania parasites undergoe post-translational modification as key regulators in several cellular processes, which represents an entire new field for drug target elucidation, once this is poorly explored. This perspective review describes the advances on antileishmanial metallodrugs and the elucidation of drug targets based on post-translational modifications, highlighting the limitations on the drug discovery/development process and suggesting standardisations focused on products addressed to who need it most |
| Disciplinas: | Medicina |
| Palabras clave: | Parasitología, Farmacología, Leishmaniasis, Metalofármacos, Blancos terapéuticos |
| Keyword: | Parasitology, Pharmacology, Leishmaniasis, Metallodrugs, Therapeutic targets |
| Texto completo: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
