Determination of medium lethal dose (LD50) and acute toxicity of formulation Cytoreg®, an ionic mixture of strong and weak acids
Título del documento: Determination of medium lethal dose (LD50) and acute toxicity of formulation Cytoreg®, an ionic mixture of strong and weak acids
Revista: Latin American Journal of Development
Base de datos: CLASE
Número de sistema: 000506420
ISSN: 2674-9297
Autores: 1
2
3
3
3
3
3
Instituciones: 1Universidad de Los Andes, Facultad de Ciencias, Mérida. Venezuela
2Universidad de Los Andes, Facultad de Medicina, Mérida. Venezuela
3Cytorex de Venezuela S.A, Caracas, Distrito Federal. Venezuela
Año:
Periodo: May-Jun
Volumen: 3
Número: 3
Paginación: 1121-1126
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Analítico
Resumen en portugués A series of toxicological and pharmacological tests were started in the bioterium of the University of Los Andes, in order to evaluate a new formulation for therapeutic purposes. The present work reports the results found regarding the LD50 and the acute toxicity of this formulation produced by Cytorex of Venezuela, S.A. The new formulation supplied in liquid form, containing a variety of acid atoms whose conjugated bases have different electrical charges. It constitutes an ion transport complex of positively charged cations and negatively charged anions in high concentrations that help regulate mitochondrial and cellular metabolism and utilizes the inorganic fluoride ion (HF) as the main active compound, as referred to by the supplier. All the concentrations described in this work are referred to hydrofluoric acid (HF), which is the active compound of the formulation. Conventional pharmacological methods were used and it was found that the average lethal dose in rats resulted in 44.83 mg/Kg, and of 0.82ml/Kg. At the concentration of minimum dose of 0,49 mL/Kg of weight, the surviving animals did not present apparent macroscopic lesions at necropsy
Disciplinas: Medicina
Palabras clave: Farmacología,
Medicina experimental,
Cytoreg,
Dosis medias letales,
Ratas
Keyword: Medicinal chemistry,
Pharmacology,
Medium lethal dose (LD50),
Toxicity,
Rats
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