| Revista: | Jornal brasileiro de patologia e medicina laboratorial |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000297225 |
| ISSN: | 1676-2444 |
| Autores: | Pracchia, Luis Fernando1 Buccheri, Valeria Menezes, Yara de Siqueira, Sheila A. C Mori, Nair Sumie Chamone, Dalton Alencar Fisher |
| Instituciones: | 1Universidade de Sao Paulo, Hospital das Clinicas, Sao Paulo. Brasil |
| Año: | 2005 |
| Periodo: | Oct |
| Volumen: | 41 |
| Número: | 5 |
| Paginación: | 365-375 |
| País: | Brasil |
| Idioma: | Portugués |
| Tipo de documento: | Artículo |
| Enfoque: | Caso clínico, analítico |
| Resumen en inglés | BACKGROUND: Nodular sclerosis (NS), a frequent histological subtype of Hodgkin´s lymphoma (HL), presents great variability in its cellular composition. In the 80's, researchers of the British National Lymphoma Investigation (BNLI) proposed a histological-based subclassification for NS HL. They identified two histological grades - NS HL grade I (NS HL I) and NS HL grade II (NS HL II) - and reported that NS II patients had a lower survival rate in comparison with NS I patients. Others studies, however, did not reproduce these findings. OBJECTIVE: Evaluate the prognostic significance of the BNLI grading system. MATERIAL AND METHOD: We retrospectively studied 69 NS HL patients. More than 90% of the included cases were treated with combined modality therapy or exclusive chemotherapy, the treatment type was not different for NS I and NS II patients. RESULTS: Thirty-five cases (51%) were classified as NS I and 34 (49%) as NS II. We did not observe significant differences in the distribution of other prognostic factors between the two NS grades. The complete remission rate after initial therapy was 85.7% in the NS I group and 82.4% in the NS II group (p = 0.75). The predicted 5-year overall survival rate was 67% in the NS I patients and 83.5% in the NS II patients (p = 0.13). The predicted 5-year disease free survival rate for NSI and NSII patients was 85.2% and 87%, respectively (p = 0.72). CONCLUSION: The histological BNLI grading system was not associated with the prognosis of this uniformly treated NS LH population |
| Resumen en portugués | CONCLUSÃO: Nesta população de pacientes uniformemente tratados a graduação histológica BNLI não esteve associada com o prognóstico do LH EN |
| Disciplinas: | Medicina |
| Palabras clave: | Diagnóstico, Oncología, Linfoma de Hodgkin, Sobrevivencia, Pronóstico, Histología, Esclerosis nodular |
| Keyword: | Medicine, Diagnosis, Oncology, Hodgkin lymphoma, Survival, Prognosis, Histology, Nodular sclerosis |
| Texto completo: | Texto completo (Ver HTML) |
