Revista: | International braz j urol |
Base de datos: | PERIÓDICA |
Número de sistema: | 000434890 |
ISSN: | 1677-5538 |
Autores: | Polat, Emre Can1 Besiroglu, Huseyin2 Ozcan, Levent3 Otunctemur, Alper1 Eruyar, Ahmet Tugrul3 Somay, Adnan4 Ozbay, Nurver4 Cekmen, Mustafa5 Eraldemir, Ceyla6 Ozbek, Emin7 |
Instituciones: | 1University of Health Sciences, Okmeydani Training and Research Hospital, Estambul. Turquía 2Catalca Ilyas Cokay State Hospital, Department of Urology, Estambul. Turquía 3University of Health Sciences, Derince Training and Research Hospital, Kocaeli. Turquía 4University of Health Sciences, Fatih Sultan Mehmet Training and Research Hospital, Estambul. Turquía 5Istanbul Medeniyet University, Department of Biochemistry, Estambul. Turquía 6Kocaeli University, Department of Biochemistry, Kocaeli. Turquía 7Istanbul University, Cerrahpasa Medical School, Estambul. Turquía |
Año: | 2018 |
Periodo: | Nov-Dic |
Volumen: | 44 |
Número: | 6 |
País: | Brasil |
Idioma: | Inglés |
Tipo de documento: | Artículo |
Enfoque: | Experimental, aplicado |
Resumen en inglés | Introduction: We investigated whether Oltipraz (OPZ) attenuated renal fibrosis in a unilateral ureteral obstruction (UUO) rat model. Materials and Methods: We randomly divided 32 rats into four groups, each consisting of eight animals as follows: Rats in group 1 underwent a sham operation and received no treatment. Rats in group 2 underwent a sham operation and received OPZ. Rats in group 3 underwent unilateral ureteral ligation and received no treatment. Group 4 rats were subjected to unilateral ureteral ligation plus OPZ administration. Transforming growth factor beta-1 (TGF-β1), E-cadherin, nitric oxide (NO) and hydroxyproline levels were measured. Histopathological and immunohistochemical examinations were carried out. Results: TGF-β1, NO and E-cadherin levels in the UUO group were significantly higher than the sham group and these values were significantly different in treated groups compared to the UUO group. In rats treated with UUO + OPZ, despite the presence of mild tubular degeneration and less severe tubular necrosis, glomeruli maintained a better morphology when compared to the UUO group. Expressions of α-SMA in immunohistochemistry showed that the staining positivity decreased in the tubules of the OPZ-treated group. Conclusions: While the precise mechanism of action remains unknown, our results demonstrated that OPZ exerted a protective role in the UUO-mediated renal fibrosis rat model highlighting a promising therapeutic potency of Nrf2-activators for alleviating the detrimental effects of unilateral obstruction in kidneys |
Disciplinas: | Medicina |
Palabras clave: | Urología, Farmacología, Insuficiencia renal, Fibrosis renal, Obstrucción ureteral, Oltipraz |
Keyword: | Urology, Pharmacology, Renal insufficiency, Oltipraz, Renal fibrosis, Ureteral stenosis |
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