| Revista: | INTERdisciplina |
| Base de datos: | CLASE |
| Número de sistema: | 000428434 |
| ISSN: | 2448-5705 |
| Autores: | Miramontes, Pedro1 Peralta, Raúl2 Garcés, Homero1 Cocho, Germinal3 |
| Instituciones: | 1Universidad Nacional Autónoma de México, Facultad de Ciencias, México, Distrito Federal. México 2Universidad Autónoma del Estado de Morelos, Centro de Investigación en Dinámica Celular, Cuernavaca, Morelos. México 3Universidad Nacional Autónoma de México, Instituto de Física, México, Distrito Federal. México |
| Año: | 2015 |
| Periodo: | May-Ago |
| Volumen: | 3 |
| Número: | 6 |
| Paginación: | 63-82 |
| País: | México |
| Idioma: | Español |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico |
| Resumen en español | médica pero, sobre todo, nos interesa contribuir a la comprensión de los mecanismos que gobiernan el tránsito de una célula de un atractor a otro |
| Resumen en inglés | Mortality data on human population cancer is overwhelming. At present, it is the third cause of death worldwide. The study of cancer has been so far centered within the genetic-molecular paradigm. However, there is currently a move towards an interdisciplinary perspective. From this point of view, a strategy for studying the dynamics of cancer transcending the limits of the reductive approaches is based on the theory of complex systems. According to this perspective, it is possible to construct a theoretical framework to study the problem as a whole, recognizing the contribution of the parts—genes—and identifying the collective action that leads to emergent properties. The theory of complex systems materializes in the mathematics of dynamic systems whose formal methodology allows the construction of gene regulatory networks of cellular phenotypes. The fate of each cell phenotype determined by the dynamics of networks of gene regulation is called the attractor of the system. In this essay we will see that these attractors are the stationary states of the networks and their evolution can be modulated by local perturbations induced by therapeutic agents. Our proposal has a potential medical benefit and proposes a theoretical framework to explain the transition from one attractor to another |
| Disciplinas: | Medicina |
| Palabras clave: | Oncología, Biología celular, Genética, Dinámica, Transformación celular, Regulación génica, Sistemas complejos, Atractores, Mecanismos moleculares |
| Texto completo: | Texto completo (Ver PDF) |
