| Revista: | Genetics and molecular biology |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000332627 |
| ISSN: | 1415-4757 |
| Autores: | Zhong, Chen1 Quanzhong, Yin1 Genshan, Ma1 Hua, Zhang1 Ruolong, Zheng1 Jiahong, Wang1 Chunheng, Gao1 |
| Instituciones: | 1The Affiliated ZhongDa Hospital of Southeast University, Department of Cardiology, Nanjing, Jiangsu. China |
| Año: | 2009 |
| Periodo: | Jun |
| Volumen: | 32 |
| Número: | 2 |
| Paginación: | 260-263 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | We investigated the association between myeloperoxidase gene -463G > A polymorphism and premature coronary artery disease (CAD) in two Chinese population samples: 229 patients and 230 controls. Genotypes were determined by ligase detection reaction-polymerase chain reaction sequencing and the grouping technique. We found lower frequencies of both the A/A genotype and the A allele in patients (p < 0.05). Multivariate logistic regression showed that the risk of premature CAD in subjects carrying the AA genotype was reduced by 83% in relation to individuals carrying the G/G genotype (OR = 0.172, 95% CI: 0.057-0.526, p = 0.002). Our results indicate that -463G > A polymorphism of the myeloperoxidase gene is associated with premature CAD in Chinese individuals, suggesting that the AA genotype is a protective factor against premature CAD |
| Disciplinas: | Medicina |
| Palabras clave: | Sistema cardiovascular, Genética, Mieloperoxidasa, Enfermedad coronaria, Predisposición genética, Polimorfismo genético |
| Keyword: | Medicine, Cardiovascular system, Genetics, Myeloperoxidase, Coronary diseases, Genetic predisposition, Genetic polymorphism |
| Texto completo: | Texto completo (Ver HTML) |
