| Revista: | Genetics and molecular biology |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000363389 |
| ISSN: | 1415-4757 |
| Autores: | Oliveira, Rodrigo Juliano1 Salles, Maria Jose Sparca2 Silva, Ariane Fernanda da2 Kanno, Tatiane Yumi Nakamura2 Lourenco, Ana Carolina dos Santos2 Leite, Vessia da Silva2 Matiazi, Hevenilton Jose3 Pesarini, João Renato1 Ribeiro, Lucia Regina4 Mantovani, Mario Sergio2 |
| Instituciones: | 1Universidade Federal de Mato Grosso do Sul, Centro de Estudos em Celulas Tronco, Terapia Celular, e Genetica Toxicologica, Campo Grande, Mato Grosso do Sul. Brasil 2Universidade Estadual de Londrina, Departamento de Biologia Geral, Londrina, Parana. Brasil 3Universidade Estadual de Londrina, Laboratório de Tecnologia em Alimentos e Medicamentos, Londrina, Parana. Brasil 4Universidade Estadual Paulista "Julio de Mesquita Filho", Instituto de Biociencias, Rio Claro, Sao Paulo. Brasil |
| Año: | 2013 |
| Periodo: | Sep |
| Volumen: | 36 |
| Número: | 3 |
| Paginación: | 413-424 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental |
| Resumen en inglés | Ample evidence suggests that cancer is triggered by mutagenic damage and diets or supplements capable of reducing such incidences can be related to the prevention of neoplasy development or to an improvement in life quality of patients who undergo chemotherapy. This research aimed to evaluate the antimutagenic and antigenotoxic activity of β-glucan. We set up 8 experimental groups: control (Group 1), cyclophosphamide (Group 2), Groups 3-5 to assess the effect of β-glucan administration, and Groups 6-8 to evaluate the association between cyclophosphamide and β-glucan. The intraperitonial concentrations of β-glucan used were 100, 150 and 200 mg/kg. Micronucleus and comet assays showed that within the first week of treatment β-glucan presented a damage reduction rate between 100-62.04% and 94.34-59.52% for mutagenic and genotoxic damages, respectively. This activity decreased as the treatment was extended. During the sixth week of treatment antimutagenicity rates were reduced to 59.51-39.83% and antigenotoxicity was not effective. This leads to the conclusion that the efficacy of β-glucan in preventing DNA damage is limited when treatment is extended, and that its use as a chemotherapeutic adjuvant need to be better clarified |
| Disciplinas: | Química, Biología |
| Palabras clave: | Fitoquímica, Química farmacéutica, Hongos, Beta-glucano, Ciclofosfamida, Antimutagenicidad, Antigenotoxicidad, Ratones |
| Keyword: | Chemistry, Biology, Medicinal chemistry, Phytochemistry, Fungi, Beta-glucan, Cyclophosphamide, Antimutagenicity, Antigenotoxicity, Mice |
| Texto completo: | Texto completo (Ver PDF) |
