| Revista: | Genetics and molecular biology |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000346150 |
| ISSN: | 1415-4757 |
| Autores: | Salles, Patricy de Andrade1 Fortes, Juliana Chagas2 Guedes, Maria Izabel Florindo2 Weller, Mathias3 |
| Instituciones: | 1Universidade Estadual do Ceara, Departamento de Medicina Veterinaria, Fortaleza, Ceara. Brasil 2Universidade Estadual do Ceara, Departamento de Nutricao, Fortaleza, Ceara. Brasil 3Universidade Estadual do Ceara, Departamento de Biologia, Fortaleza, Ceara. Brasil |
| Año: | 2007 |
| Periodo: | Sep |
| Volumen: | 30 |
| Número: | 3 |
| Paginación: | 702-708 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | The D-type cyclins form complexes with the cyclin dependent (CD) kinases CDK4 and CDK6 and promote the G1-S phase transition of the cell cycle by antagonizing the retinoblastoma suppresser protein pRB. In the developing nervous system D-type cyclins show spatially and temporally dynamic patterns of expression. We demonstrated that cyclin D1 was transiently expressed in differentiating spinal cord ventral interneurons while cyclin D3 protein was expressed in differentiating motor neurons and dorsal interneurons. This expression of cyclin D3 in neurons of the mantle zone was extended to all regions of the spinal cord at E15.5. The results suggest that cyclin D1 and D3 have specific functions in differentiating neurons. Similarly, in the developing midbrain-hindbrain region the D-type cyclins were expressed in different subsets of cells. Our results argue in favor of different functions for D-type cyclins during proliferation and differentiation of neural progenitors |
| Disciplinas: | Biología |
| Palabras clave: | Biología celular, Genética, Expresión génica, Ciclinas, Ciclo celular, Neurogénesis |
| Keyword: | Biology, Cell biology, Genetics, Gene expression, Cyclins, Cell cycle, Neurogenesis |
| Texto completo: | Texto completo (Ver HTML) |
