| Revista: | Genetics and molecular biology |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000459217 |
| ISSN: | 1415-4757 |
| Autores: | Yépez, Yuri1 Marcano Ruiz, Mariana1 Bezerra, Rafael S2 Fam, Bibiana1 Ximenez, João P.B2 Silva-Junior, Wilson A2 Bortolini, Maria Cátira1 |
| Instituciones: | 1Universidade Federal do Rio Grande do Sul, Departamento de Genetica, Porto Alegre, Rio Grande do Sul. Brasil 2Universidade de Sao Paulo, Faculdade de Medicina de Ribeirao Preto, Ribeirao Preto, Sao Paulo. Brasil |
| Año: | 2022 |
| Volumen: | 45 |
| Número: | 1 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico |
| Resumen en inglés | Our goal was to describe in more detail the evolutionary history of Gamma and two derived lineages (P.1.1 and P.1.2), which are part of the arms race that SARS-CoV-2 wages with its host. A total of 4,977 sequences of the Gamma strain of SARS-CoV-2 from Brazil were analyzed. We detected 194 sites under positive selection in 12 genes/ORFs: Spike, N, M, E, ORF1a, ORF1b, ORF3, ORF6, ORF7a, ORF7b, ORF8, and ORF10. Some diagnostic sites for Gamma lacked a signature of positive selection in our study, but these were not fixed, apparently escaping the action of purifying selection. Our network analyses revealed branches leading to expanding haplotypes with sites under selection only detected when P.1.1 and P.1.2 were considered. The P.1.2 exclusive haplotype H_5 originated from a non-synonymous mutational step (H3509Y) in H_1 of ORF1a. The selected allele, 3509Y, represents an adaptive novelty involving ORF1a of P.1. Finally, we discuss how phenomena such as epistasis and antagonistic pleiotropy could limit the emergence of new alleles (and combinations thereof) in SARS-COV-2 lineages, maintaining infectivity in humans, while providing rapid response capabilities to face the arms race triggered by host immuneresponses |
| Disciplinas: | Biología, Medicina |
| Palabras clave: | Genética, Virus, Medicina experimental, Evolución y filogenia, SARS-CoV-2, Variante gama |
| Keyword: | Genetics, Virus, Experimental medicine, Evolution and phylogeny, SARS-CoV-2, Gamma variant |
| Texto completo: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
