| Revista: | Genetics and molecular biology |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000418057 |
| ISSN: | 1415-4757 |
| Autores: | Loreto, Elgion L.S1 Depra, Marindia3 Diesel, José F2 Panzera, Yanina4 Valente-Gaiesky, Vera Lucia Silva3 |
| Instituciones: | 1Universidade Federal do Rio Grande do Sul, Programa de Pos-Graduacao em Genetica e Biologia Molecular, Porto Alegre, Rio Grande do Sul. Brasil 2Universidade Federal de Santa Maria, Departamento de Bioquimica e Biologia Molecular, Santa Maria, Rio Grande do Sul. Brasil 3Universidade Federal do Rio Grande do Sul, Departamento de Genetica, Porto Alegre, Rio Grande do Sul. Brasil 4Universidad de la República, Departamento de Genetica, Montevideo. Uruguay |
| Año: | 2018 |
| Periodo: | Mar |
| Volumen: | 41 |
| Paginación: | 198-205 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico |
| Resumen en inglés | Hypermutable strains of Drosophila simulans have been studied for 20 years. Several mutants were isolated and characterized, some of which had phenotypes associated with alteration in development; for example, showing ectopic legs with eyes being expressed in place of antennae. The causal agent of this hypermutability is a non-autonomous hobo-related sequence (hoboVA). Around 100 mobilizable copies of this element are present in the D. simulans genome, and these are likely mobilized by the autonomous and canonical hobo element. We have shown that hoboVA has transcription factor binding sites for the developmental genes, hunchback and evenskipped, and that this transposon is expressed in embryos, following the patterns of these genes. We suggest that hobo and hobo-related elements can be material for the emergence of new regulatory networks |
| Disciplinas: | Biología |
| Palabras clave: | Insectos, Genética, Evolución y filogenia, Hobo, Elementos transponibles, Secuencias reguladoras cis, Drosophila |
| Keyword: | Insects, Genetics, Evolution and phylogeny, Hobo transposon, Transposable elements, Cis-regulatory sequences, Drosophila |
| Texto completo: | Texto completo (Ver PDF) |
