APOE and KLF14 genetic variants are sex-specific for low high-density lipoprotein cholesterol identified by a genome-wide association study
Título del documento: APOE and KLF14 genetic variants are sex-specific for low high-density lipoprotein cholesterol identified by a genome-wide association study
Revista: Genetics and molecular biology
Base de datos: PERIÓDICA
Número de sistema: 000459215
ISSN: 1415-4757
Autores: 1
2
3
4
2
5
6
Instituciones: 1Kaohsiung Veterans General Hospital, Department of Pathology and Laboratory Medicine, Kaohsiung. Taiwán
2China Medical University Hospital, Center for Precision Medicine, Taichung. Taiwán
3Kaohsiung Medical University, Office of Library and Information Services, Kaohsiung. Taiwán
4Tunghai University, Department of Statistics, Taichung. Taiwán
5Kaohsiung Medical University Hospital, Department of Internal Medicine, Kaohsiung. Taiwán
6National University of Kaohsiung, Department of Kinesiology, Health and Leisure Studies, Kaohsiung. Taiwán
Año:
Volumen: 45
Número: 1
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Experimental, analítico
Resumen en inglés To demonstrate the loci that relate to high-density lipoprotein cholesterol (HDL-C) levels and genetic sex heterogeneity, we enrolled 41,526 participants aged between 30 and 70 years old from the Taiwan Biobank in a genome-wide association study. We applied the Manhattan plot to display the p-values estimated for the relationships between loci and low HDL-C. A total of 160 variants were significantly associated with low HDL-C. The genotype TT of rs1364422 located in the KLF14 gene has 1.30 (95% CI=1.20 - 1.42) times the risk for low-HDL compared to genotype CC in females (log(-p) =8.98). Moreover, the genes APOC1, APOE, PVRL2, and TOMM40 were associated significantly with low-HDL-C in males only. Excluding the variants with high linkage disequilibrium, we revealed the rs429358 located in APOE as the major genetic variant for lowering HDL-C, in which genotype CT has 1.24 (95% CI= 1.16 - 1.32) times the risk. In addition, we also examine 12 genes related to HDL-C in both sexes, including LPL, ABCA1, APOA5, BUD13, ZPR1, ALDH1A2, LIPC, CETP, HERPUD1, LIPG, ANGPTL8, and DOCK6. In conclusion, low-HDL-C is a genetic and sex-specific phenotype, and we discovered that the APOE and KLF14 are specific to low-HDL-C for men and women, respectively
Disciplinas: Biología
Palabras clave: Genética,
Sexo,
Colesterol,
Lipoproteínas,
Variantes genéticas,
Genoma
Keyword: Genetics,
Sex,
Cholesterol,
Lipoproteins,
Genetic variants,
Genome
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