A systematic review of the role of surfactants in bronchial asthma: Implications for pathogenesis and treatment of the disease
Título del documento: A systematic review of the role of surfactants in bronchial asthma: Implications for pathogenesis and treatment of the disease
Revista: Gaceta médica de Caracas
Base de datos:
Número de sistema: 000596059
ISSN: 2739-0012
Autores: 1
2
3
3
3
Instituciones: 1Pathology, Basic and Clinical Pharmaco State University, Osh, Kyrgyzstan,
2Medical Pathology Department, anakkale Onsekiz Martakkale Onsekiz Mart University, anakkale, Turkey,
3Osh State University, Osh, Kyrgyzstan,
Año:
Volumen: 132
Número: 1
País: Venezuela
Idioma: Español
Resumen en español The study aims to examine existing literature and highlight the significance of surfactants as a factor in pathogenesis and a potential therapeutic target in bronchial asthma. A systematic search is conducted in Scopus, Web of Science, and PubMed/Medline, utilizing specific keywords related to surfactants and bronchial asthma. The findings demonstrate that surfactants, a unique mixture of lipids and proteins, play a crucial role in the mechanisms of innate and adaptive immunity in the lungs. They act as a mechanical barrier, modulate inflammatory responses, and interact with pathogens. Changes in surfactant composition and levels have been associated with various lung diseases, including bronchial asthma
Palabras clave: Surfactants,
bronchial asthma,
pathogenesis,
immunomodulation,
pathophysiology
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