| Revista: | Brazilian journal of physics |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000361851 |
| ISSN: | 0103-9733 |
| Autores: | Santos, Ricardo N1 Andricopulo, Adriano D1 |
| Instituciones: | 1Universidade de Sao Paulo, Instituto de Fisica de Sao Carlos, Sao Carlos, Sao Paulo. Brasil |
| Año: | 2013 |
| Periodo: | Ago |
| Volumen: | 43 |
| Número: | 4 |
| Paginación: | 268-280 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | Medicinal chemistry is a multidisciplinary subject that integrates knowledge from a variety of fields of science, including, but not limited to, chemistry, biology, and physics. The area of drug design involves the cooperative work of scientists with a diverse range of backgrounds and technical skills, trying to tackle complex problems using an integration of approaches and methods. One important contribution to this field comes from physics through studies that attempt to identify and quantify the molecular interactions between small molecules (drugs) and biological targets (receptors), such as the forces that govern the interactions, the thermodynamics of the drug–receptor interactions, and so on. In this context, the interfaces of physics, medicinal chemistry, and drug design are of vital importance for the development of drugs that not only have the right chemistry but also the right intermolecular properties to interact at the macromolecular level, providing useful information about the principles and molecular mechanisms underlying the therapeutic action of drugs. This article highlights some of the most important connections between physics and medicinal chemistry in the design of new drugs |
| Disciplinas: | Física y astronomía, Química |
| Palabras clave: | Química farmacéutica, Diseño de fármacos, Interacciones moleculares |
| Keyword: | Physics and astronomy, Chemistry, Medicinal chemistry, Drug design, Molecular interactions |
| Texto completo: | Texto completo (Ver HTML) |
