Understanding and Targeting the Colon Cancer Pathogenesis: A Molecular Perspective



Título del documento: Understanding and Targeting the Colon Cancer Pathogenesis: A Molecular Perspective
Revista: Brazilian Journal of Pharmaceutical Sciences
Base de datos: PERIÓDICA
Número de sistema: 000451741
ISSN: 1984-8250
Autores: 1
Instituciones: 1Bezmialem Vakif University, Beykoz Institute of Life Sciences and Biotechnology, Estambul. Turquía
Año:
Volumen: 58
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Analítico, descriptivo
Resumen en inglés Colorectal cancer (CRC) one of the leading cause of cancer-related deaths worldwide. With the presently available knowledge on CRC, it is understood that the underlying is a complex process. The complexity of CRC lies in aberrant activation of several cellular signaling pathways that lead to activation and progression of CRC. In this context, recent studies have pointed towards the role of developmental pathways like; hedgehog (HH), wingless-related integration site (WNT/β-catenin) and Notch pathways that play a crucial role in maintenance and homeostasis of colon epithelium. Moreover, the deregulation of these signaling pathways has also been associated with the pathogenesis of CRC. Therefore, in the search for better therapeutic options, these pathways have emerged as potential targets. The present review attempts to highlight the role of HH, WNT/β-catenin and Notch pathways in colon carcinogenesis
Disciplinas: Medicina
Palabras clave: Oncología,
Gastroenterología,
Cáncer colorrectal,
Catenina,
Patogénesis,
Análisis molecular,
Dianas moleculares
Keyword: Oncology,
Gastroenterology,
Colorectal cancer,
Catenin,
Pathogenesis,
Molecular analysis,
Molecular targets
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