| Revista: | Brazilian Journal of Pharmaceutical Sciences |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000451482 |
| ISSN: | 1984-8250 |
| Autores: | Bretas, Ana Carolina Oliveira1 Souza, Thiago Belarmino de1 Borelli, Beatriz2 Johan, Suzana2 Alves, Ricardo José1 |
| Instituciones: | 1Universidade Federal de Minas Gerais, Faculdade de Farmacia, Belo Horizonte, Minas Gerais. Brasil 2Universidade Federal de Minas Gerais, Instituto de Ciencias Biológicas, Belo Horizonte, Minas Gerais. Brasil |
| Año: | 2020 |
| Volumen: | 56 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | Systemic fungal infections are a growing problem in contemporary medicine and few drugs are licensed for therapy of invasive fungal infections. Differences between fungi and humans, like the presence of a cell wall in fungal cells, can be explored for designing new drugs. (1,3)-β-D-glucan synthase, an enzyme that catalyzes the synthesis of (1,3)-β-D-glucan, a structural and essential component of the fungal cell wall, is absent in mammals and this makes it an excellent target for the development of new antifungal agents. Papulacandins are a family of natural antifungal agents targeting (1,3)-β-D-glucan synthase. In this study we describe the synthesis and biological evaluation of two new Papulacandin analogs as potential (1,3)-β-D-glucan synthase inhibitors |
| Disciplinas: | Química |
| Palabras clave: | Química farmacéutica, Análogos químicos, Papulacandina D, Síntesis química, Beta-(1,3)-D-glucano sintetasa, Simplificación molecular, Actividad antifúngica |
| Keyword: | Medicinal chemistry, Chemical analogues, Papulacandin D, Chemical synthesis, Antifungal activity, Beta-(1,3)-D-glucan synthase, Molecular simplification |
| Texto completo: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
