| Revista: | Brazilian Journal of Pharmaceutical Sciences |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000451685 |
| ISSN: | 1984-8250 |
| Autores: | Dong, Guijuan1 Yang, Jun1 Zhao, Xin1 Guo, Shubin1 |
| Instituciones: | 1Beijing Chaoyang Hospital Emergency Medicine Clinical Research Center, *, Beijing. China |
| Año: | 2022 |
| Volumen: | 58 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | Intestinal ischemia/reperfusion (I/R) causes barrier impairment and bacterial influx. This study explored the protective effects of anisodamine hydrobromide (AH) on intestinal I/R injury caused by cardiopulmonary resuscitation (CPR) after cardiac arrest (CA). After successful CPR, minipigs were randomly divided into two groups (n = 8): saline and AH (4 mg/kg), and then treated with saline or AH via central venous injection, respectively. The same procedures without ventricular fibrillation initiation were conducted in the Sham group (n = 8). Levels of interferon gamma (IFN-γ) and interleukin 4 (IL-4) were measured at different time points (0, 0.5, 1, 2, 4, and 6 h) in serum and 6 h in gut associated lymphoid tissues (GALTs) after the return of spontaneous circulation (ROSC) to evaluate changes in the proportion of T-helper type 1 (Th1) and T-helper type 2 (Th2). Moreover, the positive culture rates of GALTs were examined to evaluate bacterial translocation. AH treatment markedly alleviated aberrant arterial blood gas and hemodynamics as well as intestinal macroscopic and morphological changes after CPR. Moreover, AH treatment significantly increased IFN-γ and decreased IL-4 in both serum and GALTs. Furthermore, AH treatment dramatically decreased positive bacterial growth in GALTs. AH treatment mitigated immunosuppression caused by intestinal I/R and protected the intestinal immune barrier against bacterial translocation, thereby reducing the risk of secondary intestinal infection |
| Disciplinas: | Medicina |
| Palabras clave: | Sistema cardiovascular, Gastroenterología, Farmacología, Paro cardiaco, Isquemia intestinal, Translocación bacteriana, Bromhidrato de anisodamina |
| Keyword: | Cardiovascular system, Gastroenterology, Pharmacology, Heart arrest, Intestinal ischemia, Anisodamine hydrobromide, Bacterial translocation |
| Texto completo: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
