| Revista: | Brazilian Journal of Pharmaceutical Sciences |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000451249 |
| ISSN: | 1984-8250 |
| Autores: | Espinoza, Joel Toribio1 Novak, Robson Schimandeiro1 Magalhães, Cássia Gonçalves2 Budel, Jane Manfron1 Justus, Barbara1 Gonçalves, Melissa Marques3 Boscardin, Patricia Mathias Döll1 Farago, Paulo Vitor1 Paula, Josiane de Fátima Padiha De1 |
| Instituciones: | 1Universidade Estadual de Ponta Grossa, Programa de Pos-Graduacao em Ciencias Farmaceuticas, Ponta Grossa, Parana. Brasil 2Universidade Estadual de Ponta Grossa, Departamento de Quimica, Ponta Grossa, Parana. Brasil 3Universidade Federal do Parana, Programa de Pos-Graduacao em Ciencias Farmaceuticas, Curitiba, Parana. Brasil |
| Año: | 2020 |
| Volumen: | 56 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Aplicado, descriptivo |
| Resumen en inglés | The objective of this work was to develop and characterize liposomes loaded with silver nanoparticles (LAgNPs) to show improvement in stability characteristics. AgNPs were prepared by the green synthesis method with Aloe vera gel extract and exposure to sunlight. Liposomes were prepared by the modified reverse phase method. Particle size, polydispersity index, zeta potential, as well as the scanning electron microscopy (SEM) morphological aspects of AgNPs and LAgNPs were evaluated. In addition, was used flame atomic absorption spectroscopy to determine the amount of AgNP that was encapsulated in liposomes. The AgNPs presented as amorphous and polydisperse structures, with a mean diameter of 278.46 nm and zeta potential of -18.3 mV. LAgNPs had a mean diameter between 321 and 373 nm, the polydispersity index close to 0.2 and a zeta potential around -40 mV, which indicates greater stability to the AgNPs. The images obtained by SEM show semicircular structures for AgNPs and well-defined spherical shape for LAgNPs. The percentage of encapsulation was between 51.81 to 58.83%. These results showed that LAgNPs were obtained with adequate physicochemical characteristics as a release system |
| Disciplinas: | Química |
| Palabras clave: | Química farmacéutica, Liposomas, Nanopartículas de plata, Aloe vera, Química verde |
| Keyword: | Medicinal chemistry, Silver nanoparticles, Aloe vera, Green chemistry, Liposomes |
| Texto completo: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
