| Revista: | Brazilian Journal of Pharmaceutical Sciences |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000451356 |
| ISSN: | 1984-8250 |
| Autores: | Arshad, Wajeeha1 Khan, Haji Muhammad Shoaib1 Akhtar, Naveed1 Mohammad, Imran Shair2 |
| Instituciones: | 1The Islamia University of Bahawalpur, Faculty of Pharmacy and Alternative Medicines, Bahawalpur, Punjab. Pakistán 2China Pharmaceutical University, School of Pharmacy, Nanjing, Jiangsu. China |
| Año: | 2020 |
| Volumen: | 56 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | Currently, the use of natural compounds obtained from plants tremendously increased due to their promising therapeutic properties. The aim of this study was to formulate a stable emulgel formulation loaded with Cinnamomum tamala (CT) extract. The antioxidant activity of plant extract was determined by DPPH inhibition assay. The extract was successfully loaded into an emulgels using different concentrations of carbopol-940, liquid paraffin, emulsifying agents and preservatives. Preliminary stability study was performed of 17 CT emulgel formulations at accelerated temperature of 50 °C for 2-months. Organoleptic evaluation, centrifugation, globule size, pH, electrical conductivity and rheological studies were performed for a period of 90-days at different temperature including 8, 25, 40 and 40 °C ±75% RH. The CT extract showed promising antioxidant activity of about 81%. On the other hand, the CT loaded emulgel formulation displayed high physical stability at all tested conditions of temperature and time. However, slight decrease in pH and minimum increase in conductivity was observed at 40 and 40 °C±75% RH. The rheological examination of CT emulgel indicated the flow index values of all the samples kept at different temperatures were less than 1, demonstrated non-newtonian and pseudo-plastic nature of CT emulgel. Taken together, the CT emulgel formulation has been evinced to be an excellent addition in the field of topical formulations |
| Disciplinas: | Química |
| Palabras clave: | Química farmacéutica, Sistemas de liberación de fármacos, Emulgel, Estabilidad física, Extractos vegetales, Antioxidantes, Preparaciones tópicas, Cinnamomum tamala, Lauraceae |
| Keyword: | Medicinal chemistry, Drug delivery systems, Emulgel, Physical stability, Plant extracts, Antioxidants, Topic preparations, Cinnamomum tamala, Lauraceae |
| Texto completo: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
