| Revista: | Brazilian Journal of Pharmaceutical Sciences |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000451318 |
| ISSN: | 1984-8250 |
| Autores: | Rodrigues, Deborah Fernandes1 Couto, Rene Oliveira do1 Sinisterra, Rubén Dario2 Jensen, Carlos Eduardo de Matos1 |
| Instituciones: | 1Universidade Federal de Sao Joao del Rei, Campus do Meio Oeste Dona Lindu, Divinopolis, Minas Gerais. Brasil 2Universidade Federal de Minas Gerais, Departamento de Quimica, Belo Horizonte, Minas Gerais. Brasil |
| Año: | 2020 |
| Volumen: | 56 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | This paper reports on the development of nanoparticles aiming at the in vitro controlled release of simvastatin (SVT). The nanoparticles were prepared by the nanoprecipitation method with polymers Eudragit® FS30D (EDGFS) or Eudragit® NE30D (EDGNE). EDGFS+SVT nanoparticles showed mean size of 148.8 nm and entrapment efficiency of 76.4%, whereas EDGNE+SVT nanoparticles showed mean size of 105.0 nm and entrapment efficiency of 103.2%. Infrared absorption spectra demonstrated that SVT incorporated into the polymer matrix, especially EDGNE. Similarly, the differential scanning calorimeter (DSC) curve presented no endothermic peak of fusion, indicating that the system is amorphous and the drug is not in the crystalline state. The maintenance of SVT in the amorphous state may favors its solubilization in the target release sites. In the in vitro dissolution assay, the SVT incorporated into the EDGFS+SVT nanoparticles showed a rapid initial release, which may be related to the pH of the dissolution medium used. Regarding the EDGNE+SVT nanoparticles, the in vitro release occurred in a bimodal behavior, i.e., an initial “burst” followed by a sustained delivery, with the kinetics of drug release following Baker-Lonsdale’s mathematical model. All these features suggest the nanoparticulate system’s potential to modulate SVT delivery and enhance its bioavailability |
| Disciplinas: | Química |
| Palabras clave: | Química farmacéutica, Simvastatina, Liberación controlada, Nanopartículas, Poli (metacrilato de metilo), Eudragit |
| Keyword: | Medicinal chemistry, Simvastatin, Controlled release, Nanoparticles, Poly-methylmethacrylate, Eudragit |
| Texto completo: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
