| Revista: | Brazilian Journal of Pharmaceutical Sciences |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000451955 |
| ISSN: | 1984-8250 |
| Autores: | Pasupathy, Rangasamy1 Pandian, Pitchaimuthu1 Selvamuthukumar, Subramanian1 |
| Instituciones: | 1Annamalai University, Department of Pharmacy, Annamalainagar, Tamil Nadu. India |
| Año: | 2022 |
| Volumen: | 58 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | Nanobubbles are nanometer size bubbles having different constituents of varying physicochemical characteristic for the inner core and outer shell. Nanobubbles are mainly fabricated to improve the stability, bioavailability and improve the biodistribution of the delivered drug to the specific targeted site. Their small sizes bubbles allow the possibility of extravasation from blood vessels into the surrounding tissues and ultrasound-targeted site-specific release with minimal invasiveness. Nanobubbles are developing as important contrast agents for imaging and carriers for drug delivery at targeted region. Sonication is the primary method for preparation of nanobubbles followed by thin-layer evaporation, high shear emulsification, mechanical agitation and coacervation or coalescence. With exposure to ultrasound/extracorporeal shock waves, the drug is liberated from the nanobubbles into the target cells. This review paper is an effort to reveal the different formulation development techniques briefly and varying shell and core content for developing nanobubbles |
| Disciplinas: | Química |
| Palabras clave: | Química farmacéutica, Sistemas de liberación de fármacos, Nanoburbujas, Terapia génica, Trombólisis |
| Keyword: | Medicinal chemistry, Drug delivery systems, Nanobubbles, Gene therapy, Thrombolysis |
| Texto completo: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
